# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4327486 | Binding | Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-AM addition measured after 30 mins by spectrofluorimetric method | Homo sapiens | 24 | ALA4325869 | cell-based format | Scientific Literature | |
2. | ALA4327487 | Binding | Inhibition of MRP1 (unknown origin) expressed in MDCK cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-AM addition measured after 30 mins by spectrofluorimetric method | Homo sapiens | 23 | ALA4325869 | cell-based format | Scientific Literature | |
3. | ALA4327488 | Binding | Selectivity index, ratio of IC50 for MRP1 (unknown origin) expressed in MDCK cells to IC50 for MDR1 (unknown origin) expressed in MDCK cells | Homo sapiens | 22 | ALA4325869 | cell-based format | Scientific Literature | |
4. | ALA4327489 | Binding | Inhibition of MDR1 (unknown origin) expressed in MDCK cells assessed as potentiation of doxorubicin-induced cytotoxicity preincubated for 24 hrs followed by doxorubicin addition measured after 72 hrs by MTT assay | Homo sapiens | 6 | ALA4325869 | cell-based format | Scientific Literature | |
5. | ALA4327490 | ADME | Cytotoxicity against MDCK cells expressing MDR1 assessed as reduction in cell viability at 10 uM after 72 hrs by MTT assay | Canis lupus familiaris | 6 | ALA4325869 | cell-based format | Scientific Literature |