# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4325427 | Binding | Inhibition of p300 (unknown origin) using histone H3 (1 to 21 residues) as substrate preincubated for 15 mins followed by substrate and [3H]acetyl-CoA addition and measured after 60 mins by scintillation counting analysis | Homo sapiens | 28 | ALA4321876 | single protein format | Scientific Literature | |
2. | ALA4325428 | Functional | Antiproliferative activity against human MV4-11 cells measured after 3 days by celltiter-glo luminescence assay | Homo sapiens | 28 | ALA4321876 | cell-based format | Scientific Literature | |
3. | ALA4325429 | ADME | Intrinsic clearance in human liver microsomes assessed per mg protein at 0.1 uM preincubated for 10 mins followed by NADPH addition and measured up to 60 mins by UPLC-MS/MS analysis | Homo sapiens | 28 | ALA4321876 | microsome format | Scientific Literature | |
4. | ALA4325430 | ADME | Intrinsic clearance in rat liver microsomes assessed per mg protein at 0.1 uM preincubated for 10 mins followed by NADPH addition and measured up to 60 mins by UPLC-MS/MS analysis | Rattus norvegicus | 28 | ALA4321876 | microsome format | Scientific Literature | |
5. | ALA4325431 | ADME | Intrinsic clearance in mouse liver microsomes assessed per mg protein at 0.1 uM preincubated for 10 mins followed by NADPH addition and measured up to 60 mins by UPLC-MS/MS analysis | Mus musculus | 28 | ALA4321876 | microsome format | Scientific Literature | |
6. | ALA4325432 | ADME | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4321876 | organism-based format | Scientific Literature | |
7. | ALA4325433 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4321876 | organism-based format | Scientific Literature | |
8. | ALA4325434 | ADME | AUClast in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4321876 | organism-based format | Scientific Literature | |
9. | ALA4325435 | ADME | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4321876 | organism-based format | Scientific Literature | |
10. | ALA4325436 | ADME | Half life in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 9 | ALA4321876 | organism-based format | Scientific Literature | |
11. | ALA4325437 | ADME | Tmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 9 | ALA4321876 | organism-based format | Scientific Literature | |
12. | ALA4325438 | ADME | Cmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 9 | ALA4321876 | organism-based format | Scientific Literature | |
13. | ALA4325439 | ADME | AUClast in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 9 | ALA4321876 | organism-based format | Scientific Literature | |
14. | ALA4325440 | ADME | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4321876 | organism-based format | Scientific Literature | |
15. | ALA4325441 | ADME | Protein binding in rat plasma | Rattus norvegicus | 4 | ALA4321876 | cell-free format | Scientific Literature |