| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4371947 | Binding | Inhibition of human transmembrane domain deficient FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mins by fluorescence assay | Homo sapiens | 27 | ALA4371025 | assay format | Scientific Literature | |
| 2. | ALA4371948 | Binding | Inhibition of rat FFAH expressed in Escherichia coli using AAMCA as substrate incubated for 1 min measured for 50 mins by fluorescence assay | Rattus norvegicus | 24 | ALA4371025 | assay format | Scientific Literature | |
| 3. | ALA4371950 | ADME | Intrinsic metabolic stability in human liver microsomes assessed as metabolic turnover rate per mg protein at 1 uM preincubated for 5 mins followed by NADPH cofactor addition and measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 15 | ALA4371025 | microsome format | Scientific Literature | |
| 4. | ALA4371951 | ADME | Intrinsic metabolic stability in rat liver microsomes assessed as metabolic turnover over per mg protein at 1 uM preincubated for 5 mins followed by NADPH cofactor addition and measured after 30 mins by LC-MS/MS analysis | Rattus norvegicus | 15 | ALA4371025 | microsome format | Scientific Literature | |
| 5. | ALA4371952 | ADME | AUC (0 to 48 hrs) in Sprague-Dawley rat at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4371025 | organism-based format | Scientific Literature | |
| 6. | ALA4371954 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4371025 | organism-based format | Scientific Literature | |
| 7. | ALA4371956 | ADME | Clearance in Sprague-Dawley rat at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4371025 | organism-based format | Scientific Literature | |
| 8. | ALA4371958 | ADME | Elimination half life in Sprague-Dawley rat at 3 mg/kg, iv administered as single dose by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4371025 | organism-based format | Scientific Literature | |
| 9. | ALA4371960 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg, po administered as single dose via gavage by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4371025 | organism-based format | Scientific Literature | |
| 10. | ALA4371962 | ADME | AUC (0 to 48 hrs) in plasma of Sprague-Dawley rat at 10 mg/kg, po administered as single dose via gavage by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4371025 | organism-based format | Scientific Literature | |
| 11. | ALA4371964 | ADME | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg administered as single dose via gavage by LC-MS/MS analysis | Rattus norvegicus | 5 | ALA4371025 | organism-based format | Scientific Literature | |
| 12. | ALA4371966 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4371025 | microsome format | Scientific Literature | |
| 13. | ALA4371967 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4371025 | microsome format | Scientific Literature | |
| 14. | ALA4371968 | ADME | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured after 40 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4371025 | microsome format | Scientific Literature | |
| 15. | ALA4371969 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4371025 | microsome format | Scientific Literature | |
| 16. | ALA4371970 | ADME | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4371025 | microsome format | Scientific Literature | |
| 17. | ALA4371971 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH cofactor addition and measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4371025 | microsome format | Scientific Literature | |
| 18. | ALA4371972 | ADME | Clearance in Sprague-Dawley rat at 3 mg/kg, iv or 10 mg/kg, po administered as single dose via gavage by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4371025 | organism-based format | Scientific Literature | |
| 19. | ALA4371973 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 3 mg/kg, iv or 10 mg/kg, po administered as single dose via gavage by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4371025 | organism-based format | Scientific Literature | |
| 20. | ALA4371974 | ADME | Elimination half life in Sprague-Dawley rat at 3 mg/kg, iv or 10 mg/kg, po administered as single dose via gavage by LC-MS/MS analysis | Rattus norvegicus | 4 | ALA4371025 | organism-based format | Scientific Literature |
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