# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4404890 | Binding | Stabilization of c-Kit1 G4 quadruplex DNA assessed as change in melting temperature at 10 mol.equiv by circular dichroism melting assay | Not specified | 15 | ALA4402581 | nucleic acid format | Scientific Literature | |
2. | ALA4404891 | Binding | Stabilization of c-Kit2 G4 quadruplex DNA assessed as change in melting temperature at 10 mol.equiv by circular dichroism melting assay | Not specified | 15 | ALA4402581 | nucleic acid format | Scientific Literature | |
3. | ALA4404892 | Binding | Stabilization of c-Myc G4 quadruplex DNA assessed as change in melting temperature at 10 mol.equiv by circular dichroism melting assay | Not specified | 15 | ALA4402581 | nucleic acid format | Scientific Literature | |
4. | ALA4404893 | Binding | Stabilization of parallel Tel23 G4 quadruplex DNA assessed as change in melting temperature at 10 mol.equiv by circular dichroism melting assay | Not specified | 15 | ALA4402581 | nucleic acid format | Scientific Literature | |
5. | ALA4404894 | Binding | Stabilization of human Tel23 G4 quadruplex DNA assessed as change in melting temperature at 10 mol.equiv by circular dichroism melting assay | Homo sapiens | 15 | ALA4402581 | nucleic acid format | Scientific Literature | |
6. | ALA4404895 | Binding | Stabilization of hairpin-duplex DNA assessed as change in melting temperature at 10 mol.equiv by circular dichroism melting assay | Not specified | 15 | ALA4402581 | assay format | Scientific Literature | |
7. | ALA4404907 | Functional | Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 1 hr followed by 48 hrs of recovery in drug free medium by MTT assay | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
8. | ALA4404908 | Functional | Cytotoxicity against human U2OS cells assessed as reduction in cell viability incubated for 24 hrs followed by 48 hrs of recovery in drug-free medium by MTT assay | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
9. | ALA4404909 | Functional | Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 1 hr followed by 48 hrs of recovery in drug free medium by MTT assay | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
10. | ALA4404910 | Functional | Cytotoxicity against human HeLa cells assessed as reduction in cell viability incubated for 24 hrs followed by 48 hrs of recovery in drug free medium by MTT assay | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
11. | ALA4404912 | Binding | Stabilization of G4 quadruplex DNA in human U2OS cells assessed as increase in number of G4 foci at 10 uM incubated for 24 hrs by immunofluorescence microscopy | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
12. | ALA4404915 | Binding | Stabilization of G4 quadruplex DNA in human U2OS cells assessed as colocalization of TRF2/BGF4 foci at 10 uM incubated for 24 hrs by immunofluorescence microscopy (Rvb = 18.4 +/- 2.81%) | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
13. | ALA4404917 | Binding | Stabilization of G4 quadruplex DNA in human U2OS cells assessed as TRF2 foci per cell at 10 uM incubated for 24 hrs by immunofluorescence microscopy (Rvb = 15.8 +/- 2.6%) | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
14. | ALA4404918 | Functional | Induction of DNA:RNA hybrid formation in human U2OS cells assessed as increase in R loop formation at 10 uM incubated for 30 mins by S9.6 immunofluorescence microscopy | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
15. | ALA4404919 | Functional | Induction of DNA:RNA hybrid formation in human U2OS cells assessed as increase in R loop formation at 10 uM incubated for 60 mins by S9.6 immunofluorescence microscopy | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
16. | ALA4404920 | Functional | Induction of DNA damage in human U2OS cells assessed as increase in gammaH2AX phosphorylation at S139 at 10 uM incubated for 4 hrs by immunofluorescence microscopy | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
17. | ALA4404921 | Functional | Induction of DNA damage in human U2OS cells assessed as increase in phosphorylated 53BPI foci colocalization with gammaH2AX foci at 10 uM incubated for 4 hrs by immunofluorescence microscopy | Homo sapiens | 2 | ALA4402581 | cell-based format | Scientific Literature | |
18. | ALA4404922 | Functional | Induction of genome instability in human U2OS cells assessed as increase in micronuclei formation at 10 uM incubated for 24 hrs by immunofluorescence microscopy | Homo sapiens | 1 | ALA4402581 | cell-based format | Scientific Literature | |
19. | ALA4404924 | Binding | Effect on c-Kit1 G4 quadruplex DNA architecture at 10 mol.equiv by circular dichroism spectral analysis | Not specified | 15 | ALA4402581 | nucleic acid format | Scientific Literature | |
20. | ALA4404925 | Binding | Effect on c-Kit2 G4 quadruplex DNA architecture at 10 mol.equiv by circular dichroism spectral analysis | Not specified | 15 | ALA4402581 | nucleic acid format | Scientific Literature |