# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4310373 | Binding | Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in peak current amplitude at 30 uM at -60 mV holding potential treated for 12 secs followed by compound washout for 181 secs by whole cell two electrode voltage-clamp assay relative to ACh | Homo sapiens | 28 | ALA4308856 | cell-based format | Scientific Literature | |
2. | ALA4310374 | Binding | Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge at 30 uM at -60 mV holding potential treated for 12 secs followed by compound washout for 181 secs by whole cell two electrode voltage-clamp assay relative to ACh | Homo sapiens | 28 | ALA4308856 | cell-based format | Scientific Literature | |
3. | ALA4310375 | Binding | Ratio of partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in peak current amplitude relative to ACh to partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge relative to ACh | Homo sapiens | 28 | ALA4308856 | cell-based format | Scientific Literature | |
4. | ALA4310376 | Binding | Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge at 30 uM at -60 mV holding potential treated for 12 secs followed by compound washout for 181 secs in presence of type 2 PAM PNU-120596 by whole cell two electrode voltage-clamp assay relative to ACh | Homo sapiens | 28 | ALA4308856 | cell-based format | Scientific Literature | |
5. | ALA4310377 | Binding | Ratio of Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge in presence of type 2 PAM PNU-120596 relative to ACh to partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as increase in net charge relative to ACh | Homo sapiens | 28 | ALA4308856 | cell-based format | Scientific Literature |