| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4330680 | ADME | Cytotoxicity against human SH-SY5Y cells assessed as cell viability at 10 uM after 48 hrs by MTT assay (Rvb = 100%) | Homo sapiens | 13 | ALA4330068 | cell-based format | Scientific Literature | |
| 2. | ALA4330682 | Functional | Neuroprotective activity in human SH-SY5Y cells assessed as reduction in MPP+ induced cytotoxicity by measuring cell viability at 1 uM preincubated for 2 hrs followed by MPP+ addition and measured after 48 hrs by MTT assay (Rvb = 45%) | Homo sapiens | 13 | ALA4330068 | cell-based format | Scientific Literature | |
| 3. | ALA4330683 | Functional | Neuroprotective activity in human SH-SY5Y cells assessed as reduction in MPP+ induced cytotoxicity at 5 to 10 uM preincubated for 2 hrs followed by MPP+ addition measured after 48 hrs by MTT assay | Homo sapiens | 13 | ALA4330068 | cell-based format | Scientific Literature | |
| 4. | ALA4330684 | Binding | Inhibition of voltage-dependent L-type calcium channel in human SH-SY5Y cells assessed as reduction in KCl-stimulated calcium influx at 10 uM preincubated for 30 mins in presence of Mag-Fura-2/AM dye followed by KCl stimulation and measured over 35 secs by fluorescence assay (Rvb =100%) | Homo sapiens | 16 | ALA4330068 | cell-based format | Scientific Literature | |
| 5. | ALA4330686 | Binding | Antagonist activity at NMDA receptor in human SH-SY5Y cells assessed as reduction in NMDA/glycine-stimulated calcium influx at 10 uM preincubated for 30 mins in presence of Mag-Fura-2/AM dye followed by NMDA/glycine stimulation and measured over 35 secs by fluorescence assay (Rvb = 100%) | Homo sapiens | 16 | ALA4330068 | cell-based format | Scientific Literature | |
| 6. | ALA4330687 | ADME | Inhibition of recombinant human MAO-A using kynuramine as substrate after 20 mins by fluorescence assay | Homo sapiens | 14 | ALA4330068 | single protein format | Scientific Literature | |
| 7. | ALA4330688 | Binding | Inhibition of recombinant human MAO-B using kynuramine as substrate after 20 mins by fluorescence assay | Homo sapiens | 15 | ALA4330068 | single protein format | Scientific Literature | |
| 8. | ALA4330689 | Binding | Selectivity index, ratio of IC50 for recombinant human MAO-A to IC50 for recombinant human MAO-B | Homo sapiens | 8 | ALA4330068 | assay format | Scientific Literature | |
| 9. | ALA4330691 | Binding | Reversible inhibition of recombinant human MAO-B at 2 times IC50 preincubated up to 60 mins followed by kynuramine substrate addition and measured after 20 mins by fluorescence assay | Homo sapiens | 5 | ALA4330068 | single protein format | Scientific Literature |
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