# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4421993 | F | Cytotoxicity against human RPMI8226 cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
2. | ALA4421994 | F | Cytotoxicity against human NCI-H929 cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
3. | ALA4421995 | F | Cytotoxicity against human HL60 cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
4. | ALA4421996 | F | Cytotoxicity against human KG1a cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
5. | ALA4421997 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
6. | ALA4421998 | F | Cytotoxicity against human SK-UT-1 cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
7. | ALA4421999 | F | Cytotoxicity against human Flow 2000 cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
8. | ALA4422000 | A | Cytotoxicity against human WI38 cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
9. | ALA4422001 | A | Cytotoxicity against human PBMC cells assessed as reduction in cell viability incubated for 72 hrs by CT-Glo cytotoxicity assay | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
10. | ALA4422002 | B | Binding affinity to nuclear export signal of topoisomerase 2alpha in human NCI-H929 cells assessed as potentiation of doxorubicin-induced apoptosis by measuring increase in cleaved caspase-3 levels at 25 uM pre-incubated for 20 hrs followed by addition of doxorubicin for 4 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
11. | ALA4422003 | B | Binding affinity to nuclear export signal of topoisomerase 2alpha in human RPMI8226 cells assessed as potentiation of doxorubicin-induced apoptosis by measuring increase in cleaved caspase-3 levels at 25 uM pre-incubated for 20 hrs followed by addition of doxorubicin for 4 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
12. | ALA4422004 | B | Binding affinity to nuclear export signal of topoisomerase 2alpha in human U266 cells assessed as potentiation of doxorubicin-induced apoptosis by measuring increase in cleaved caspase-3 levels at 25 uM pre-incubated for 20 hrs followed by addition of doxorubicin for 4 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
13. | ALA4422005 | F | Induction of apoptosis in human NCI-H929 cells assessed as increase in cleaved caspase-3 levels at 25 uM incubated for 20 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
14. | ALA4422006 | F | Induction of apoptosis in human RPMI8226 cells assessed as increase in cleaved caspase-3 levels at 25 uM incubated for 20 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
15. | ALA4422007 | F | Induction of apoptosis in human U266 cells assessed as increase in cleaved caspase-3 levels at 25 uM incubated for 20 hrs | Homo sapiens | 7 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
16. | ALA4422008 | B | Inhibition of nuclear export of topoisomerase 2alpha in human NCI-H929 cells assessed as increase in nuclear top2alpha level at 25 uM by immunofluorescence microscopy relative to control | Homo sapiens | 3 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
17. | ALA4422009 | B | Binding affinity to nuclear export signal of topoisomerase 2alpha in human NCI-H929 cells assessed as potentiation of doxorubicin-induced apoptosis by measuring increase in cleaved caspase-3 levels at 25 uM pre-incubated for 20 hrs followed by addition of doxorubicin for 4 hrs relative to control | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
18. | ALA4422010 | B | Inhibition of decatenation activity of human topoisomerase 2 using kinetoplast DNA up to 50 uM incubated for 30 mins by agarose gel electrophoresis | Homo sapiens | 4 | ALA4421723 | protein format | Patent Bioactivity Data | |
19. | ALA4422011 | A | Effect on Top2alpha protein levels in human RPMI8226 cells at 25 uM incubated for 20 hrs by Western blot analysis | Homo sapiens | 4 | ALA4421723 | cell-based format | Patent Bioactivity Data | |
20. | ALA4422014 | B | Inhibition of nuclear export signal of topoisomerase 2alpha in human NCI-H929 cells assessed as reduction in cytoplasmic localization of Top2alpha at 100 uM incubated for 24 hrs by Western blot analysis | Homo sapiens | 5 | ALA4421723 | cell-based format | Patent Bioactivity Data |