# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4356096 | Binding | Inhibition of HIF1alpha transcriptional activity in hypoxia-induced human HCCLM3 cells co-transfected with luciferase reporter plasmid containing five copies of HREs and pRL-SV40 plasmid encoding Renilla luciferase at 10 uM incubated with compound under normoxia for 1 hr followed by hypoxia induction and measured after 24 hrs by HRE-dependent dual luciferase reporter gene assay relative to control | Homo sapiens | 70 | ALA4354811 | assay format | Scientific Literature | |
2. | ALA4356100 | Binding | Inhibition of HIF1alpha transcriptional activity in hypoxia-induced human HCCLM3 cells co-transfected with luciferase reporter plasmid containing five copies of HREs and pRL-SV40 plasmid encoding Renilla luciferase incubated with compound under normoxia for 1 hr followed by hypoxia induction and measured after 24 hrs by HRE-dependent dual luciferase reporter gene assay | Homo sapiens | 17 | ALA4354811 | assay format | Scientific Literature | |
3. | ALA4356101 | ADME | Cytotoxicity against human HCCLM3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay | Homo sapiens | 16 | ALA4354811 | cell-based format | Scientific Literature |