# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4413939 | Functional | Antiviral activity against HCV genotype 1b replicon infected in human HuH7 cells after 72 hrs by bright-glo luciferase reporter gene assay | Hepacivirus hominis | 31 | ALA4411327 | organism-based format | Scientific Literature | |
2. | ALA4413942 | Functional | Antiviral activity against HCV genotype 1b replicon infected in human HuH7 cells at 10 uM after 72 hrs by bright-glo luciferase reporter gene assay relative to control | Hepacivirus hominis | 8 | ALA4411327 | organism-based format | Scientific Literature | |
3. | ALA4413943 | ADME | Cytotoxicity against human HuH7 cells infected with HCV genotype 1b replicon after 72 hrs by CellTiter-Fluor reagent based fluorescence assay | Homo sapiens | 32 | ALA4411327 | cell-based format | Scientific Literature | |
4. | ALA4413944 | ADME | Prodrug conversion in simulated gastric fluid assessed as sofosbuvir formation | 3 | ALA4411327 | assay format | Scientific Literature | ||
5. | ALA4413945 | ADME | Half life in human plasma at 40 uM by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | cell-free format | Scientific Literature | |
6. | ALA4413946 | ADME | Stability in human plasma assessed as parent compound remaining at 40 uM measured immediately by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | cell-free format | Scientific Literature | |
7. | ALA4413947 | ADME | Stability in human plasma assessed as parent compound remaining at 40 uM measured after 0.5 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | cell-free format | Scientific Literature | |
8. | ALA4413948 | ADME | Stability in human plasma assessed as parent compound remaining at 40 uM measured after 1 hr by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | cell-free format | Scientific Literature | |
9. | ALA4413949 | ADME | Stability in human plasma assessed as parent compound remaining at 40 uM measured after 2 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | cell-free format | Scientific Literature | |
10. | ALA4413950 | ADME | Stability in human plasma assessed as parent compound remaining at 40 uM measured after 5 hrs by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | cell-free format | Scientific Literature | |
11. | ALA4413951 | ADME | Half life in human liver microsomes at 0.1 uM preincubated with MgCl2 for 10 mins followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | microsome format | Scientific Literature | |
12. | ALA4413952 | ADME | Stability in human liver microsomes assessed as parent compound remaining at 0.1 uM preincubated with MgCl2 for 10 mins followed by NADPH addition measured immediately by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | microsome format | Scientific Literature | |
13. | ALA4413953 | ADME | Stability in human liver microsomes assessed as parent compound remaining at 0.1 uM preincubated with MgCl2 for 10 mins followed by NADPH addition measured after 7 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | microsome format | Scientific Literature | |
14. | ALA4413954 | ADME | Stability in human liver microsomes assessed as parent compound remaining at 0.1 uM preincubated with MgCl2 for 10 mins followed by NADPH addition measured after 17 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | microsome format | Scientific Literature | |
15. | ALA4413955 | ADME | Stability in human liver microsomes assessed as parent compound remaining at 0.1 uM preincubated with MgCl2 for 10 mins followed by NADPH addition measured after 30 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | microsome format | Scientific Literature | |
16. | ALA4413956 | ADME | Stability in human liver microsomes assessed as parent compound remaining at 0.1 uM preincubated with MgCl2 for 10 mins followed by NADPH addition measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | microsome format | Scientific Literature | |
17. | ALA4413957 | ADME | Metabolic bioavailability in human liver microsomes at 0.1 uM preincubated with MgCl2 for 10 mins followed by NADPH addition measured within 60 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4411327 | organism-based format | Scientific Literature |