# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4350055 | B | Inhibition of human PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mins by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4350056 | B | Inhibition of mouse PDS stably expressed in FRT cells coexpressing EYFP-H148Q/I152L/F46L assessed as reduction in I-/Cl- exchange incubated for 10 mins by fluorescence based assay | Mus musculus | 17 | cell-based format | Scientific Literature | ||
3. | ALA4418132 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated anion exchange at 25 uM incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 22 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4418133 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
5. | ALA4418134 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17F exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4418135 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated Cl(-)/r exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4418136 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17NO3(-) exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4418137 | B | Reversible inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange incubated for 10 mins measured after wash out by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
9. | ALA4418138 | B | Time dependent inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4418139 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17HCO3(-) exchange by measuring reduction in cytoplasmic alkalinization exchange at 25 uM by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4418140 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17HCO3(-) exchange by measuring reduction in cytoplasmic alkalinization exchange at 2.5 uM by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4418141 | B | Inhibition of ENaC in human bronchial epithelial cells assessed as effect on short-circuit current at 25 uM pre-incubated for 30 mins | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
13. | ALA4418142 | B | Inhibition of CFTR in human bronchial epithelial cells assessed as effect on short-circuit current at 25 uM pre-incubated for 30 mins | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
14. | ALA4418143 | B | Inhibition of CaCC in human bronchial epithelial cells assessed as effect on short-circuit current at 25 uM pre-incubated for 30 mins | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
15. | ALA4418144 | B | Inhibition of potassium channel in human bronchial epithelial cells assessed as effect on short-circuit current at 25 uM pre-incubated for 30 mins | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
16. | ALA4418145 | B | Inhibition of NKCC1 in human bronchial epithelial cells assessed as effect on short-circuit current at 25 uM pre-incubated for 30 mins | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
17. | ALA4418146 | B | Inhibition of human SLC26A3 expressed in COS7 co-expressing EYFP-HIF assessed as reduction in SCN gradient | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
18. | ALA4418147 | F | Effect on gluconate gradient-induced Cl(-) efflux in NHBE cells at 25 uM | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
19. | ALA4418148 | F | Effect on gluconate gradient-induced Cl/HC03- efflux in NHBE cells at 25 uM | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data | ||
20. | ALA4418149 | B | Inhibition of pendrin in IL13-stimulated human bronchial epithelial cells assessed as reduction in gluconate gradient-induced intracellular alkalization at 25 uM | Homo sapiens | 1 | cell-based format | Patent Bioactivity Data |