# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4402801 | Binding | Binding affinity to synthetic BCL2 G4 quadruplex DNA assessed as change in melting temperature at 10 molar equiv to DNA measured after 10 mins by circular dichroism melting analysis | Not specified | 19 | ALA4402513 | nucleic acid format | Scientific Literature | |
2. | ALA4402802 | Binding | Binding affinity to synthetic c-MYC G4 quadruplex DNA assessed as change in melting temperature at 10 molar equiv to DNA measured after 10 mins by circular dichroism melting analysis | Not specified | 19 | ALA4402513 | nucleic acid format | Scientific Literature | |
3. | ALA4402803 | Binding | Binding affinity to synthetic c-KIT1 G4 quadruplex DNA assessed as change in melting temperature at 10 molar equiv to DNA measured after 10 mins by circular dichroism melting analysis | Not specified | 19 | ALA4402513 | nucleic acid format | Scientific Literature | |
4. | ALA4402804 | Binding | Binding affinity to human telomeric 23 G4 quadruplex DNA assessed as change in melting temperature at 10 molar equiv to DNA measured after 10 mins by circular dichroism melting analysis | Homo sapiens | 19 | ALA4402513 | nucleic acid format | Scientific Literature | |
5. | ALA4402805 | Binding | Binding affinity to synthetic 20-mer hairpin duplex DNA assessed as change in melting temperature at 10 molar equiv to DNA measured after 10 mins by circular dichroism melting analysis | Not specified | 19 | ALA4402513 | assay format | Scientific Literature | |
6. | ALA4402807 | Functional | Cytotoxicity against human Jurkat cells assessed as cell viability at 50 uM measured after 48 hrs by combined MTT and trypan blue staining based cell counting assay relative to control | Homo sapiens | 2 | ALA4402513 | cell-based format | Scientific Literature | |
7. | ALA4402813 | Functional | Induction of apoptosis in human Jurkat cells assessed as viable cells at 25 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 97%) | Homo sapiens | 3 | ALA4402513 | cell-based format | Scientific Literature | |
8. | ALA4402814 | Functional | Induction of apoptosis in human Jurkat cells assessed as early apoptotic cells at 25 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 0.3%) | Homo sapiens | 3 | ALA4402513 | cell-based format | Scientific Literature | |
9. | ALA4402815 | Functional | Induction of apoptosis in human Jurkat cells assessed as late apoptotic cells at 25 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.4%) | Homo sapiens | 3 | ALA4402513 | cell-based format | Scientific Literature | |
10. | ALA4402816 | Functional | Induction of apoptosis in human Jurkat cells assessed as late apoptotic cells at 25 uM measured after 48 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 1.3%) | Homo sapiens | 3 | ALA4402513 | cell-based format | Scientific Literature | |
11. | ALA4402817 | Functional | Down regulation of c-MYC mRNA expression in human Jurkat cells at 25 uM measured after 24 hrs by RT-qPCR analysis relative to control | Homo sapiens | 3 | ALA4402513 | cell-based format | Scientific Literature | |
12. | ALA4402818 | Functional | Down regulation of BCL2 mRNA expression in human Jurkat cells at 25 uM measured after 24 hrs by RT-qPCR analysis relative to control | Homo sapiens | 2 | ALA4402513 | cell-based format | Scientific Literature | |
13. | ALA4402819 | Functional | Down regulation of c-MYC expression in human Jurkat cells at 25 uM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA4402513 | cell-based format | Scientific Literature | |
14. | ALA4402820 | Functional | Down regulation of BCL2 expression in human Jurkat cells at 25 uM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 3 | ALA4402513 | cell-based format | Scientific Literature |