# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4313180 | Binding | Inhibition of human NPP1 expressed in COS-7 cell membranes assessed as reduction in p-nitrophenol production at 100 uM using pNP-TMP as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured after 35 mins relative to control | Homo sapiens | 4 | ALA4311954 | cell-based format | Scientific Literature | |
2. | ALA4313181 | Binding | Inhibition of human NPP3 expressed in COS-7 cell membranes assessed as reduction in p-nitrophenol production using pNP-TMP as substrate preincubated with enzyme for 15 mins followed by substrate addition and measured after 35 mins | Homo sapiens | 7 | ALA4311954 | cell-based format | Scientific Literature | |
3. | ALA4313183 | Functional | Antiproliferative activity against human A549 cells assessed as cell viability at 10 uM after 72 hrs by MTT assay relative to control | Homo sapiens | 11 | ALA4311954 | cell-based format | Scientific Literature | |
4. | ALA4313184 | Functional | Antiproliferative activity against human MCF7 cells assessed as cell viability at 10 uM after 72 hrs by MTT assay relative to control | Homo sapiens | 11 | ALA4311954 | cell-based format | Scientific Literature | |
5. | ALA4313185 | Functional | Antiproliferative activity against human HT-29 cells assessed as cell viability at 10 uM after 72 hrs by MTT assay relative to control | Homo sapiens | 11 | ALA4311954 | cell-based format | Scientific Literature | |
6. | ALA4313186 | Functional | Antiproliferative activity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 5 | ALA4311954 | cell-based format | Scientific Literature | |
7. | ALA4313187 | Functional | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 5 | ALA4311954 | cell-based format | Scientific Literature | |
8. | ALA4313188 | Functional | Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 5 | ALA4311954 | cell-based format | Scientific Literature | |
9. | ALA4313189 | ADME | Cytotoxicity against human F180 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 5 | ALA4311954 | cell-based format | Scientific Literature |