# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4316844 | Binding | Inhibition of HFIP-pretreated amyloid beta (1 to 42 residues) (unknown origin) self aggregation at 25 uM after 7 days by ThT-based fluorometric method relative to control | Homo sapiens | 12 | ALA4316585 | single protein format | Scientific Literature | |
2. | ALA4316845 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurodegeneration in human SH-SY5Y cells assessed as cell viability at 10 uM preincubated for 4 hrs followed by amyloid beta (1 to 42) addition and measured after 48 hrs by MTS assay (Rvb = 60.4%) | Homo sapiens | 10 | ALA4316585 | cell-based format | Scientific Literature | |
3. | ALA4316846 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurodegeneration in human SH-SY5Y cells assessed as cell viability at 1 uM preincubated for 4 hrs followed by amyloid beta (1 to 42) addition and measured after 48 hrs by MTS assay (Rvb = 55.1%) | Homo sapiens | 4 | ALA4316585 | cell-based format | Scientific Literature | |
4. | ALA4316847 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurodegeneration in human SH-SY5Y cells assessed as cell viability at 0.5 uM preincubated for 4 hrs followed by amyloid beta (1 to 42) addition and measured after 48 hrs by MTS assay (Rvb = 55.1%) | Homo sapiens | 4 | ALA4316585 | cell-based format | Scientific Literature | |
5. | ALA4316848 | Functional | Neuroprotective activity against amyloid beta (1 to 42)-induced neurodegeneration in human SH-SY5Y cells assessed as increase in cell viability at 1 uM preincubated for 4 hrs followed by amyloid beta (1 to 42) addition after 48 hrs by micrograph method | Homo sapiens | 3 | ALA4316585 | cell-based format | Scientific Literature | |
6. | ALA4316849 | Toxicity | Neurotoxicity against human SH-SY5Y cells assessed as cell viability at 10 to 40 uM after 24 hrs by MTT assay relative to control | Homo sapiens | 10 | ALA4316585 | cell-based format | Scientific Literature | |
7. | ALA4316850 | Functional | Inhibition of amyloid beta (1 to 42)-induced lipid peroxidation in human SH-SY5Y cells at 10 uM incubated for 48 hrs by BODIPY-C11'581/591 probe-based flow cytometric analysis | Homo sapiens | 1 | ALA4316585 | cell-based format | Scientific Literature | |
8. | ALA4316852 | Functional | Inhibition of erastin-induced ferroptosis in HEK293 cells preincubated for 4 hrs followed by erastin stimulation and measured at next day by MTS assay | Homo sapiens | 4 | ALA4316585 | cell-based format | Scientific Literature | |
9. | ALA4316853 | Functional | Inhibition of (1S,3R)-RSL3-induced ferroptosis in HEK293 cells preincubated for 4 hrs followed by erastin stimulation and measured at next day by MTS assay | Homo sapiens | 4 | ALA4316585 | cell-based format | Scientific Literature |