# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4306826 | Binding | Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assay | Homo sapiens | 29 | ALA4304769 | cell-based format | Scientific Literature | |
2. | ALA4306827 | Binding | Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assay relative to control | Homo sapiens | 28 | ALA4304769 | cell-based format | Scientific Literature | |
3. | ALA4306828 | Physicochemical | 1-Octanol/PBS buffer distribution coefficient, log D of the compound at pH 7.4 | 28 | ALA4304769 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4306829 | Physicochemical | Thermodynamic solubility of the compound in aqueous phosphate buffer at pH 7.4 measured after 24 hrs by UPLC-MS/MS-based shake-flask method | 28 | ALA4304769 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4306830 | ADME | Intrinsic clearance in rat hepatocytes assessed per 10'6 cells | Rattus norvegicus | 17 | ALA4304769 | cell-based format | Scientific Literature | |
6. | ALA4306847 | Binding | Agonist activity at human His6-tcs-RORalpha LBD assessed as PGC1alpha peptide (130 to 154 residues) recruitment incubated for 1 hr by FRET assay | Homo sapiens | 17 | ALA4304769 | single protein format | Scientific Literature | |
7. | ALA4306853 | Binding | Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator peptide measured after 15 mins by FRET assay relative to control | Homo sapiens | 26 | ALA4304769 | single protein format | Scientific Literature | |
8. | ALA4306854 | Binding | Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measured after 15 mins by FRET assay | Homo sapiens | 28 | ALA4304769 | single protein format | Scientific Literature | |
9. | ALA4306858 | Binding | Inverse agonist activity at RORalpha (unknown origin) | Homo sapiens | 17 | ALA4304769 | single protein format | Scientific Literature |