#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4414121	Binding	Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay	Homo sapiens	16	ALA4411333	assay format	Scientific Literature
2.	ALA4414122	Binding	Inhibition of of SHP2 in human KYSE520 cells assessed as suppression of ERK phosphorylation after 2 hrs by AlphaScreen SureFire Phospho-ERK1/2 assay	Homo sapiens	15	ALA4411333	cell-based format	Scientific Literature
3.	ALA4414123	Functional	Antiproliferative activity against human KYSE520 cells after 24 hrs by Celltiter-Glo reagent-based assay	Homo sapiens	14	ALA4411333	cell-based format	Scientific Literature
4.	ALA4414124	Binding	Inhibition of human ERG by Q-patch assay	Homo sapiens	15	ALA4411333	single protein format	Scientific Literature
5.	ALA5098591	Physicochemical	Dissociation constant, pKa of the compound		6	ALA5096203	small-molecule physicochemical format	Scientific Literature
6.	ALA5098594	Binding	Inhibition of N-terminal his6-tagged wild type recombinant human SHP2 (1 to 597 residues) expressed in Escherichia coli BL21 (DE3) cells using fluorogenic 6,8-difluoro-4-methylumbelliferyl phosphate as substrate pretreated for 30 mins followed by substrate addition and measured after 1 hr by fluorescence assay	Homo sapiens	42	ALA5096203	cell-based format	Scientific Literature
7.	ALA5098595	Binding	Inhibition of human SHP2 assessed as downregulation of PERK level in human KYSE520 cells incubated for 2 hrs by Alpha screen assay	Homo sapiens	16	ALA5096203	cell-based format	Scientific Literature
8.	ALA5098600	ADME	Permeability of compound across apical to basolateral side in dog wild type MDCK cells	Canis lupus familiaris	6	ALA5096203	cell-based format	Scientific Literature
9.	ALA5098601	ADME	Permeability of compound across basolateral to apical side in dog wild type MDCK cells	Canis lupus familiaris	6	ALA5096203	cell-based format	Scientific Literature
10.	ALA5098602	ADME	Permeability of compound across apical to basolateral side in dog wild type MDCK-MDR1 cells	Canis lupus familiaris	6	ALA5096203	cell-based format	Scientific Literature
11.	ALA5098603	ADME	Permeability of compound across basolateral to apical side in dog wild type MDCK-MDR1 cells	Canis lupus familiaris	6	ALA5096203	cell-based format	Scientific Literature
12.	ALA5098616	Toxicity	Inhibition of hERG ion channel incubated for 3 hrs by fluorescence polarization assay	Homo sapiens	10	ALA5096203	assay format	Scientific Literature