# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4345241 | B | Activation of human Nav1.2 expressed in CHOK1 cells assessed as ratio of compound activation AUC to baseline activation AUC at 3.3 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 4 | ALA4342489 | cell-based format | Scientific Literature | |
2. | ALA4345242 | B | Activation of human Nav1.3 expressed in CHOK1 cells assessed as ratio of compound activation AUC to baseline activation AUC at 3.3 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 4 | ALA4342489 | cell-based format | Scientific Literature | |
3. | ALA4345243 | B | Activation of Nav1.1 in C57BL/6 mouse GABAergic cortical neurons assessed as rescue of ICA-121431-induced neuronal firing loss at 300 nM at holding potential -65 mV by current clamp assay | Mus musculus | 1 | ALA4342489 | single protein format | Scientific Literature | |
4. | ALA4345244 | B | Activation of human Nav1.1 expressed in HEK293 cells assessed as ratio of compound activation AUC to baseline activation AUC at 0.12 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 18 | ALA4342489 | cell-based format | Scientific Literature | |
5. | ALA4345245 | B | Activation of human Nav1.1 expressed in HEK293 cells assessed as ratio of compound activation AUC to baseline activation AUC at 0.37 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 18 | ALA4342489 | cell-based format | Scientific Literature | |
6. | ALA4345246 | B | Activation of human Nav1.1 expressed in HEK293 cells assessed as ratio of compound activation AUC to baseline activation AUC at 1.11 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 18 | ALA4342489 | cell-based format | Scientific Literature | |
7. | ALA4345247 | B | Activation of human Nav1.1 expressed in HEK293 cells assessed as ratio of compound activation AUC to baseline activation AUC at 3.3 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 18 | ALA4342489 | cell-based format | Scientific Literature | |
8. | ALA4345248 | B | Activation of human Nav1.4 expressed in HEK293 cells assessed as ratio of compound activation AUC to baseline activation AUC at 3.3 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 4 | ALA4342489 | cell-based format | Scientific Literature | |
9. | ALA4345249 | B | Activation of human Nav1.5 expressed in HEK293 cells assessed as ratio of compound activation AUC to baseline activation AUC at 3.3 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 4 | ALA4342489 | cell-based format | Scientific Literature | |
10. | ALA4345250 | B | Activation of human Nav1.6 expressed in HEK293 cells assessed as ratio of compound activation AUC to baseline activation AUC at 3.3 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 4 | ALA4342489 | cell-based format | Scientific Literature | |
11. | ALA4345251 | B | Activation of human Nav1.7 expressed in HEK293 cells assessed as ratio of compound activation AUC to baseline activation AUC at 3.3 uM at -120 mV holding potential by Qpatch assay | Homo sapiens | 4 | ALA4342489 | cell-based format | Scientific Literature |