# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4339649 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 33 | ALA4339196 | cell-based format | Scientific Literature | |
2. | ALA4339650 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2A expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 2 | ALA4339196 | cell-based format | Scientific Literature | |
3. | ALA4339651 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2C expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 2 | ALA4339196 | cell-based format | Scientific Literature | |
4. | ALA4339652 | B | Negative allosteric modulation of recombinant human GluN1a/GluN2D expressed in CHO-T-REx cells assessed as inhibition of glutamate/glycine-induced response preincubated for 5 mins followed by glutamate/glycine addition and measured after 5 mins by calcium 5 dye based FLIPR TETRA analysis | Homo sapiens | 2 | ALA4339196 | cell-based format | Scientific Literature | |
5. | ALA4339654 | P | Solubility of the compound at pH 2 | 3 | ALA4339196 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4339655 | P | Solubility of the compound at pH 7 | 3 | ALA4339196 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4339656 | B | Displacement of [3H]-1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methylphenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)ethanone from rat adult cortex GluN2B receptor measured after 2 hrs by liquid scintillation counting analysis | Rattus norvegicus | 27 | ALA4339196 | assay format | Scientific Literature | |
8. | ALA4339657 | A | Extraction ratio in human liver microsomes at 1 uM measured up to 60 mins in presence of NADPH by LC/MS/MS analysis | Homo sapiens | 25 | ALA4339196 | microsome format | Scientific Literature | |
9. | ALA4339659 | A | Inhibition of CYP2C19 in human liver microsomes | Homo sapiens | 22 | ALA4339196 | microsome format | Scientific Literature | |
10. | ALA4339661 | A | Inhibition of CYP2C9 in human liver microsomes | Homo sapiens | 25 | ALA4339196 | microsome format | Scientific Literature | |
11. | ALA4339665 | B | Displacement of [3H]dofetilide from recombinant human ERG expressed in HEK293 cell membranes measured after 80 mins by TopCount scintillation analysis | Homo sapiens | 30 | ALA4339196 | cell-based format | Scientific Literature | |
12. | ALA4339666 | A | Efflux ratio of apparent permeability from basolateral to apical over apical to basolateral side in MDCK-MDR1 cells at 5 uM after 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 17 | ALA4339196 | cell-based format | Scientific Literature |