# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4391709 | Binding | Inhibition of ovine COX1 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA method | Ovis aries | 25 | ALA4390656 | single protein format | Scientific Literature | |
2. | ALA4391711 | Binding | Potency index, ratio of indomethacin IC50 to test compound IC50 for inhibition of human recombinant COX2 | Homo sapiens | 5 | ALA4390656 | single protein format | Scientific Literature | |
3. | ALA4391712 | Binding | Potency index, ratio of diclofenac IC50 to test compound IC50 for inhibition of human recombinant COX2 | Homo sapiens | 5 | ALA4390656 | single protein format | Scientific Literature | |
4. | ALA4391713 | Binding | Selectivity index, ratio of IC50 for ovine COX1 to IC50 for human recombinant COX2 | 25 | ALA4390656 | assay format | Scientific Literature | ||
5. | ALA4391714 | Binding | Inhibition of soya bean 15-LOX by colorimetric lipoxygenase inhibitor screening assay kit method | Glycine max | 12 | ALA4390656 | assay format | Scientific Literature | |
6. | ALA4391715 | Binding | Inhibition of human recombinant COX2 catalytic activity using arachidonic acid as substrate pre-incubated for 10 mins followed by substrate addition and measured after 2 mins by ELISA method | Homo sapiens | 25 | ALA4390656 | single protein format | Scientific Literature | |
7. | ALA4391716 | Functional | Antidiabetic activity in Wistar rat hemi-diaphragm at 2 mg assessed as increase in insulin-induced glucose uptake by GOD/POD enzymatic method | Rattus norvegicus | 10 | ALA4390656 | tissue-based format | Scientific Literature | |
8. | ALA4391717 | Functional | Antidiabetic activity in Wistar rat hemi-diaphragm at 2 mg assessed as increase in glucose uptake in absence of insulin by GOD/POD enzymatic method | Rattus norvegicus | 10 | ALA4390656 | tissue-based format | Scientific Literature | |
9. | ALA4391718 | Binding | Induction of PPARgamma nuclear translocation in rat primary adipocytes at 10 uM incubated for 3 hrs by DAPI/FITC staining based immunofluorescence method | Rattus norvegicus | 5 | ALA4390656 | cell-based format | Scientific Literature | |
10. | ALA4391719 | Binding | Transactivation of GAL4 DBD-fused human PPARgamma LBD expressed in HEK293 cells at 10 uM after 24 hrs by luciferase reporter gene assay relative to control | Homo sapiens | 5 | ALA4390656 | cell-based format | Scientific Literature | |
11. | ALA4391720 | Binding | Transactivation of GAL4 DBD-fused human PPARgamma LBD expressed in HEK293 cells at 10 uM after 24 hrs by luciferase reporter gene assay relative to pioglitazone | Homo sapiens | 4 | ALA4390656 | cell-based format | Scientific Literature | |
12. | ALA4391721 | Functional | Inhibition of PMA-induced human THP1 monocytes differentiation in to macrophages assessed as macrophage metabolic activity preincubated for 6 hrs before PMA stimulation | Homo sapiens | 6 | ALA4390656 | cell-based format | Scientific Literature | |
13. | ALA4391725 | Functional | Antiinflammatory activity in rat acute inflammation model assessed as inhibition of formalin-induced paw edema at 5 mg/kg, po measured after 4 hrs relative to control | Rattus norvegicus | 6 | ALA4390656 | organism-based format | Scientific Literature | |
14. | ALA4391726 | Functional | Antiinflammatory activity in rat acute inflammation model assessed as inhibition of formalin-induced paw edema at 5 mg/kg, po measured after 4 hrs relative to celecoxib | Rattus norvegicus | 5 | ALA4390656 | organism-based format | Scientific Literature | |
15. | ALA4391727 | Functional | Antiinflammatory activity in rat acute inflammation model assessed as inhibition of formalin-induced paw edema at 5 mg/kg, po measured after 4 hrs relative to diclofenac | Rattus norvegicus | 4 | ALA4390656 | organism-based format | Scientific Literature |