# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4420225 | Functional | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as suppression of light-induced retinal function loss by measuring Rod-a and b-wave responses at 50 mg/kg, ip dosed 0.5 hrs before 6 hrs light exposure and measured 7 days after light-exposure by electroretinography | Rattus norvegicus | 2 | ALA4420061 | organism-based format | Patent Bioactivity Data | |
2. | ALA4420226 | Functional | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as suppression of light-induced retinal structure loss at 50 mg/kg, ip dosed 0.5 hrs before 6 hrs light exposure and measured 7 days after light-exposure by electroretinography | Rattus norvegicus | 2 | ALA4420061 | organism-based format | Patent Bioactivity Data | |
3. | ALA4420227 | Functional | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as suppression of light-induced retinal function loss by measuring Rod-a and b-wave responses at 50 mg/kg, ip dosed 0.5 hrs after 6 hrs light exposure and measured 7 days after light-exposure by electroretinography | Rattus norvegicus | 2 | ALA4420061 | organism-based format | Patent Bioactivity Data | |
4. | ALA4420228 | Functional | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as suppression of light-induced retinal structure loss at 50 mg/kg, ip dosed 0.5 hrs after 6 hrs light exposure and measured 7 days after light-exposure by electroretinography | Rattus norvegicus | 2 | ALA4420061 | organism-based format | Patent Bioactivity Data | |
5. | ALA4420233 | Functional | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as suppression of light-induced retinal function loss by measuring preservation of cone function at 50 mg/kg, ip dosed 0.5 to 12 hrs before 6 hrs light exposure and measured 7 days after light-exposure by electroretinography | Rattus norvegicus | 2 | ALA4420061 | organism-based format | Patent Bioactivity Data | |
6. | ALA4420234 | Functional | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as suppression of light-induced retinal function loss by measuring preservation of cone function at 50 mg/kg, ip dosed 16 to 24 hrs before 6 hrs light exposure and measured 7 days after light-exposure by electroretinography | Rattus norvegicus | 2 | ALA4420061 | organism-based format | Patent Bioactivity Data | |
7. | ALA4420235 | Functional | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as suppression of light-induced retinal function loss by measuring preservation of cone function at 50 mg/kg, ip dosed after 6 hrs light exposure and measured 7 days after light-exposure by electroretinography | Rattus norvegicus | 2 | ALA4420061 | organism-based format | Patent Bioactivity Data | |
8. | ALA4420245 | Binding | Inhibition of RPE65 in rat RPE microsomes assessed as reduction in isomero-hydrolase activity by measuring 11-cis-retinol generation using all-trans-[3H]-retinol by HPLC analysis | Rattus norvegicus | 2 | ALA4420061 | assay format | Patent Bioactivity Data | |
9. | ALA4420247 | Binding | Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in isomero-hydrolase activity using all-trans-[3H]-retinol by normal phase HPLC with flow scintillation analysis | Bos taurus | 11 | ALA4420061 | assay format | Patent Bioactivity Data | |
10. | ALA4420263 | Functional | Inhibition of rhodopsin regeneration in completely light-adapted mouse BALB/c mouse assessed as rhodopsin recovery level by measuring effect on rhodopsin content at 5% dosed to eyes via eye drop before dark adaptation for 1 hr by spectrophotometry (Rvb = 78.83%) | Mus musculus | 10 | ALA4420061 | organism-based format | Patent Bioactivity Data |