| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4397301 | B | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity at 0.2 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 2. | ALA4397302 | B | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity at 0.2 to 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 3. | ALA4397303 | B | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 4. | ALA4397304 | B | Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 60 mins by fluorescence method | Homo sapiens | 7 | subcellular format | Scientific Literature | ||
| 5. | ALA4397306 | B | Inhibition of bovine liver beta-glucosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis | Bos taurus | 8 | assay format | Scientific Literature | ||
| 6. | ALA4397308 | B | Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis | Canavalia ensiformis | 8 | single protein format | Scientific Literature | ||
| 7. | ALA4397309 | B | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity at 2 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4397313 | B | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as effect on Lysosomal alpha-mannosidase activity at 0.002 to 0.02 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 9. | ALA4397319 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 0.2 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 10. | ALA4397320 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 0.002 to 0.02 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA4397321 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 2 to 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA4397322 | B | Chaperone activity at Lysosomal alpha-mannosidase P356R mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 2 to 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 6 | single protein format | Scientific Literature | ||
| 13. | ALA4397325 | B | Chaperone activity at Lysosomal alpha-mannosidase R750W mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as enzyme activity enhancement at 2 nM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 14. | ALA4397327 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in total LAMAN at 0.2 uM incubated for 96 hrs by Western blot analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 15. | ALA4397328 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as reduction in cholesterol accumulation at 0.2 uM incubated for 96 hrs by Amplex red cholesterol assay relative to wild-type control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 16. | ALA4397329 | A | Chaperone activity at Lysosomal alpha-mannosidase in human fibroblasts assessed as reduction in cholesterol accumulation at 0.2 uM incubated for 96 hrs by Amplex red cholesterol assay | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 17. | ALA4397345 | B | Inhibition of yeast alpha-glucosidase assessed as residual hydrolytic activity up to 2 mM after 10 to 30 mins by spectrophotometric analysis | Saccharomyces cerevisiae | 7 | assay format | Scientific Literature | ||
| 18. | ALA4397346 | B | Inhibition of yeast isomaltase assessed as residual hydrolytic activity up to 2 mM after 10 to 30 mins by spectrophotometric analysis | Saccharomyces cerevisiae | 7 | assay format | Scientific Literature | ||
| 19. | ALA4397347 | B | Inhibition of Aspergillus niger amyloglucosidase assessed as residual hydrolytic activity up to 2 mM after 10 to 30 mins by spectrophotometric analysis | Aspergillus niger | 7 | assay format | Scientific Literature | ||
| 20. | ALA4397348 | B | Inhibition of green coffee alpha-galactosidase assessed as residual hydrolytic activity up to 2 mM after 10 to 30 mins by spectrophotometric analysis | Coffea arabica | 7 | single protein format | Scientific Literature |
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