# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4397301 | Binding | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity at 0.2 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | ALA4396870 | single protein format | Scientific Literature | |
2. | ALA4397302 | Binding | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity at 0.2 to 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 6 | ALA4396870 | single protein format | Scientific Literature | |
3. | ALA4397303 | Binding | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method | Homo sapiens | 6 | ALA4396870 | single protein format | Scientific Literature | |
4. | ALA4397304 | Binding | Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 60 mins by fluorescence method | Homo sapiens | 7 | ALA4396870 | subcellular format | Scientific Literature | |
5. | ALA4397306 | Binding | Inhibition of bovine liver beta-glucosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis | Bos taurus | 8 | ALA4396870 | assay format | Scientific Literature | |
6. | ALA4397308 | Binding | Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis | Canavalia ensiformis | 8 | ALA4396870 | single protein format | Scientific Literature | |
7. | ALA4397309 | Binding | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity at 2 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 1 | ALA4396870 | single protein format | Scientific Literature | |
8. | ALA4397313 | Binding | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as effect on Lysosomal alpha-mannosidase activity at 0.002 to 0.02 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | ALA4396870 | single protein format | Scientific Literature | |
9. | ALA4397319 | Binding | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 0.2 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | ALA4396870 | single protein format | Scientific Literature | |
10. | ALA4397320 | Binding | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 0.002 to 0.02 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | ALA4396870 | single protein format | Scientific Literature | |
11. | ALA4397321 | Binding | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 2 to 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 2 | ALA4396870 | single protein format | Scientific Literature | |
12. | ALA4397322 | Binding | Chaperone activity at Lysosomal alpha-mannosidase P356R mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 2 to 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 6 | ALA4396870 | single protein format | Scientific Literature | |
13. | ALA4397325 | Binding | Chaperone activity at Lysosomal alpha-mannosidase R750W mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as enzyme activity enhancement at 2 nM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 3 | ALA4396870 | single protein format | Scientific Literature | |
14. | ALA4397327 | Binding | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in total LAMAN at 0.2 uM incubated for 96 hrs by Western blot analysis | Homo sapiens | 2 | ALA4396870 | single protein format | Scientific Literature | |
15. | ALA4397328 | Binding | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as reduction in cholesterol accumulation at 0.2 uM incubated for 96 hrs by Amplex red cholesterol assay relative to wild-type control | Homo sapiens | 3 | ALA4396870 | single protein format | Scientific Literature | |
16. | ALA4397329 | ADME | Chaperone activity at Lysosomal alpha-mannosidase in human fibroblasts assessed as reduction in cholesterol accumulation at 0.2 uM incubated for 96 hrs by Amplex red cholesterol assay | Homo sapiens | 3 | ALA4396870 | single protein format | Scientific Literature | |
17. | ALA4397345 | Binding | Inhibition of yeast alpha-glucosidase assessed as residual hydrolytic activity up to 2 mM after 10 to 30 mins by spectrophotometric analysis | Saccharomyces cerevisiae | 7 | ALA4396870 | assay format | Scientific Literature | |
18. | ALA4397346 | Binding | Inhibition of yeast isomaltase assessed as residual hydrolytic activity up to 2 mM after 10 to 30 mins by spectrophotometric analysis | Saccharomyces cerevisiae | 7 | ALA4396870 | assay format | Scientific Literature | |
19. | ALA4397347 | Binding | Inhibition of Aspergillus niger amyloglucosidase assessed as residual hydrolytic activity up to 2 mM after 10 to 30 mins by spectrophotometric analysis | Aspergillus niger | 7 | ALA4396870 | assay format | Scientific Literature | |
20. | ALA4397348 | Binding | Inhibition of green coffee alpha-galactosidase assessed as residual hydrolytic activity up to 2 mM after 10 to 30 mins by spectrophotometric analysis | Coffea arabica | 7 | ALA4396870 | single protein format | Scientific Literature |