| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4345130 | B | Inhibition of recombinant full-length N-terminal His6-tagged human IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR peptide as substrate after 90 mins by fluorescence polarisation assay | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 2. | ALA4345131 | B | Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation and measured after 3.5 hrs by MSD assay | Homo sapiens | 14 | tissue-based format | Scientific Literature | ||
| 3. | ALA4345133 | B | Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation and measured after 3.5 hrs by MSD assay relative to control | Homo sapiens | 14 | tissue-based format | Scientific Literature | ||
| 4. | ALA4345134 | A | Protein binding in human plasma at 5 uM incubated for 6 hrs by red equilibrium dialysis based LC-MS/MS analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 5. | ALA4345135 | A | Apparent permeability across apical to basolateral side in dog MDCKI cells at 10 uM measured after 60 to 180 mins by lucifer yellow dye based LC-MS/MS analysis | Canis lupus familiaris | 13 | cell-based format | Scientific Literature | ||
| 6. | ALA4345136 | A | Clearance in mouse plasma at 1 mg/kg, iv or po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 7. | ALA4345137 | A | Clearance in rat plasma at 1 mg/kg, iv or po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4345138 | A | Clearance in dog plasma at 1 mg/kg, iv or po | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4345139 | A | Clearance in cynomolgus monkey plasma at 1 mg/kg, iv or po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4345140 | A | Volume of distribution at steady state in mouse at 1 mg/kg, iv or po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA4345141 | A | Volume of distribution at steady state in rat at 1 mg/kg, iv or po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4345142 | A | Volume of distribution at steady state in dog at 1 mg/kg, iv or po | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4345143 | A | Volume of distribution at steady state in cynomolgus monkey at 1 mg/kg, iv or po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4345144 | A | Half life in mouse at 1 mg/kg, iv or po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA4345145 | A | Half life in rat at 1 mg/kg, iv or po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4345146 | A | Half life in dog at 1 mg/kg, iv or po | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4345147 | A | Half life in cynomolgus monkey at 1 mg/kg, iv or po | Macaca fascicularis | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4345148 | A | AUC (infinity) in mouse at 1 mg/kg, iv or po | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA4345149 | A | AUC (infinity) in rat at 1 mg/kg, iv or po | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4345150 | A | AUC (infinity) in dog at 1 mg/kg, iv or po | Canis lupus familiaris | 1 | organism-based format | Scientific Literature |
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