#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4345130	B	Inhibition of recombinant full-length N-terminal His6-tagged human IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR peptide as substrate after 90 mins by fluorescence polarisation assay	Homo sapiens	19	ALA4342485	assay format	Scientific Literature
2.	ALA4345131	B	Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation and measured after 3.5 hrs by MSD assay	Homo sapiens	14	ALA4342485	tissue-based format	Scientific Literature
3.	ALA4345133	B	Inhibition of IRAK4 in human whole blood assessed as inhibition of R848-induced IL-6 production preincubated for 90 mins followed by R848 stimulation and measured after 3.5 hrs by MSD assay relative to control	Homo sapiens	14	ALA4342485	tissue-based format	Scientific Literature
4.	ALA4345134	A	Protein binding in human plasma at 5 uM incubated for 6 hrs by red equilibrium dialysis based LC-MS/MS analysis	Homo sapiens	1	ALA4342485	cell-free format	Scientific Literature
5.	ALA4345135	A	Apparent permeability across apical to basolateral side in dog MDCKI cells at 10 uM measured after 60 to 180 mins by lucifer yellow dye based LC-MS/MS analysis	Canis lupus familiaris	13	ALA4342485	cell-based format	Scientific Literature
6.	ALA4345136	A	Clearance in mouse plasma at 1 mg/kg, iv or po	Mus musculus	3	ALA4342485	organism-based format	Scientific Literature
7.	ALA4345137	A	Clearance in rat plasma at 1 mg/kg, iv or po	Rattus norvegicus	1	ALA4342485	organism-based format	Scientific Literature
8.	ALA4345138	A	Clearance in dog plasma at 1 mg/kg, iv or po	Canis lupus familiaris	1	ALA4342485	organism-based format	Scientific Literature
9.	ALA4345139	A	Clearance in cynomolgus monkey plasma at 1 mg/kg, iv or po	Macaca fascicularis	1	ALA4342485	organism-based format	Scientific Literature
10.	ALA4345140	A	Volume of distribution at steady state in mouse at 1 mg/kg, iv or po	Mus musculus	3	ALA4342485	organism-based format	Scientific Literature
11.	ALA4345141	A	Volume of distribution at steady state in rat at 1 mg/kg, iv or po	Rattus norvegicus	1	ALA4342485	organism-based format	Scientific Literature
12.	ALA4345142	A	Volume of distribution at steady state in dog at 1 mg/kg, iv or po	Canis lupus familiaris	1	ALA4342485	organism-based format	Scientific Literature
13.	ALA4345143	A	Volume of distribution at steady state in cynomolgus monkey at 1 mg/kg, iv or po	Macaca fascicularis	1	ALA4342485	organism-based format	Scientific Literature
14.	ALA4345144	A	Half life in mouse at 1 mg/kg, iv or po	Mus musculus	3	ALA4342485	organism-based format	Scientific Literature
15.	ALA4345145	A	Half life in rat at 1 mg/kg, iv or po	Rattus norvegicus	1	ALA4342485	organism-based format	Scientific Literature
16.	ALA4345146	A	Half life in dog at 1 mg/kg, iv or po	Canis lupus familiaris	1	ALA4342485	organism-based format	Scientific Literature
17.	ALA4345147	A	Half life in cynomolgus monkey at 1 mg/kg, iv or po	Macaca fascicularis	1	ALA4342485	organism-based format	Scientific Literature
18.	ALA4345148	A	AUC (infinity) in mouse at 1 mg/kg, iv or po	Mus musculus	3	ALA4342485	organism-based format	Scientific Literature
19.	ALA4345149	A	AUC (infinity) in rat at 1 mg/kg, iv or po	Rattus norvegicus	1	ALA4342485	organism-based format	Scientific Literature
20.	ALA4345150	A	AUC (infinity) in dog at 1 mg/kg, iv or po	Canis lupus familiaris	1	ALA4342485	organism-based format	Scientific Literature