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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4394894 Binding Inhibition of wild-type N-terminal TEV cleavage site-fused/His-tagged Mycobacterium tuberculosis H37Rv adenosine kinase expressed in Escherichia coli BL21 (DE3) using adenosine as substrate in presence of ATP and PEP by pyruvate kinase-lactate dehydrogenase coupled UV-vis spectrophotometric method Mycobacterium tuberculosis H37Rv 17 ALA4393679 assay format Scientific Literature 2. ALA4394897 Functional Antimycobacterial activity against Mycobacterium tuberculosis MC2 7000 after 6 days by micro plate alamar blue assay Mycobacterium tuberculosis 13 ALA4393679 organism-based format Scientific Literature 3. ALA4394898 ADME Cytotoxicity against HDF cells assessed as reduction in cell viability measured after 48 hrs by resazurin dye-based assay Homo sapiens 13 ALA4393679 cell-based format Scientific Literature 4. ALA4394900 Binding Competitive-inhibition of wild-type N-terminal TEV cleavage site-fused/His-tagged Mycobacterium tuberculosis H37Rv adenosine kinase expressed in Escherichia coli BL21 (DE3) using varying levels of adenosine as substrate in presence of ATP and PEP by pyruvate kinase-lactate dehydrogenase-coupled UV-vis spectrophotometric based Cheng-Prusoff equation analysis Mycobacterium tuberculosis H37Rv 1 ALA4393679 assay format Scientific Literature 5. ALA4394901 ADME Inhibition of recombinant human adenosine kinase expressed in Escherichia coli BL21 (DE3) using adenosine as substrate in presence of ATP and PEP by pyruvate kinase-lactate dehydrogenase-coupled UV-vis spectrophotometric assay Homo sapiens 12 ALA4393679 assay format Scientific Literature 6. ALA4394902 ADME Cmax in ND4 Swiss Webster mouse at 10 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 7. ALA4394903 ADME Tmax in ND4 Swiss Webster mouse at 10 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 8. ALA4394904 ADME AUC in ND4 Swiss Webster mouse at 10 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 9. ALA4394905 Toxicity Toxicity in ND4 Swiss Webster mouse at 10 mg/kg, po administered as single dose via gavage Mus musculus 1 ALA4393679 organism-based format Scientific Literature 10. ALA4394906 ADME Cmax in ND4 Swiss Webster mouse at 50 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 11. ALA4394907 ADME Cmax in ND4 Swiss Webster mouse at 100 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 12. ALA4394908 ADME Cmax in ND4 Swiss Webster mouse at 200 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 13. ALA4394909 ADME Tmax in ND4 Swiss Webster mouse at 50 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 14. ALA4394910 ADME Tmax in ND4 Swiss Webster mouse at 100 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 15. ALA4394911 ADME Tmax in ND4 Swiss Webster mouse at 200 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 16. ALA4394912 ADME AUC in ND4 Swiss Webster mouse at 50 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 17. ALA4394913 ADME AUC in ND4 Swiss Webster mouse at 100 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 18. ALA4394914 ADME AUC in ND4 Swiss Webster mouse at 200 mg/kg, po administered as single dose via gavage by LC-MS analysis Mus musculus 1 ALA4393679 organism-based format Scientific Literature 19. ALA4394915 Toxicity Toxicity in ND4 Swiss Webster mouse at 50 to 200 mg/kg, po administered once daily via gavage for 3 days measured twice daily during compound dosing Mus musculus 1 ALA4393679 organism-based format Scientific Literature 20. ALA4394916 Toxicity Toxicity in ND4 Swiss Webster mouse assessed as change in body weight at 50 to 200 mg/kg, po administered once daily via gavage for 3 days measured twice daily during compound dosing Mus musculus 1 ALA4393679 organism-based format Scientific Literature