# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4367190 | B | Antagonist activity at CCR4 in human CCRF-CEM cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay | Homo sapiens | 21 | ALA4364292 | cell-based format | Scientific Literature | |
2. | ALA4367191 | F | Antagonist activity at human CCR4 expressed in rat chem-5 cells assessed as inhibition of CCL22-induced calcium flux measured at 2.5 secs time interval for 45 secs by fluorescence assay | Homo sapiens | 30 | ALA4364292 | cell-based format | Scientific Literature | |
3. | ALA4367199 | A | Stability in human hepatocytes assessed as compound remaining incubated for 60 mins under shaking condition by LC-MS/MS analysis | Homo sapiens | 8 | ALA4364292 | cell-based format | Scientific Literature | |
4. | ALA4367200 | A | Stability in rat hepatocytes assessed as compound remaining incubated for 60 mins under shaking condition by LC-MS/MS analysis | Rattus norvegicus | 8 | ALA4364292 | cell-based format | Scientific Literature | |
5. | ALA4367206 | B | Antagonist activity at CCR4 in anti-CD3/CD28 stimulated mouse Treg cells assessed as inhibition of CCL22-mediated chemotaxis in presence of 100% human serum pre-incubated for 30 mins followed by CCL22 addition and measured after 60 mins by chemoTX probe based CellTiter-Glo assay | Mus musculus | 2 | ALA4364292 | assay format | Scientific Literature | |
6. | ALA4367207 | A | Clearance in mouse | Mus musculus | 2 | ALA4364292 | organism-based format | Scientific Literature | |
7. | ALA4367208 | A | Volume of distribution at steady state in mouse | Mus musculus | 2 | ALA4364292 | organism-based format | Scientific Literature | |
8. | ALA4367209 | A | Half-life in mouse | Mus musculus | 2 | ALA4364292 | organism-based format | Scientific Literature | |
9. | ALA4367210 | A | Bioavailability in mouse | Mus musculus | 2 | ALA4364292 | organism-based format | Scientific Literature |