# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4324209 | Binding | Inhibition of human ASK1 using myelin basic protein substrate pre-incubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-binding method | Homo sapiens | 26 | ALA4321844 | single protein format | Scientific Literature | |
2. | ALA4324210 | Binding | Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hr | Homo sapiens | 26 | ALA4321844 | cell-based format | Scientific Literature | |
3. | ALA4324211 | ADME | Apparent permeability from apical to basolateral side in MDCK-MDR1 cells | Canis lupus familiaris | 27 | ALA4321844 | cell-based format | Scientific Literature | |
4. | ALA4324212 | ADME | Efflux ratio in MDCK-MDR1 cells | Canis lupus familiaris | 27 | ALA4321844 | cell-based format | Scientific Literature | |
5. | ALA4324213 | ADME | Clearance in rat liver microsomes | Rattus norvegicus | 23 | ALA4321844 | microsome format | Scientific Literature | |
6. | ALA4324214 | ADME | Clearance in human liver microsomes | Homo sapiens | 23 | ALA4321844 | microsome format | Scientific Literature | |
7. | ALA4324215 | ADME | Unbound fraction in rat plasma at 1 uM incubated for 4 hrs by rapid equilibrium dialysis method | Rattus norvegicus | 22 | ALA4321844 | cell-free format | Scientific Literature | |
8. | ALA4324216 | ADME | Unbound fraction in human plasma at 1 uM incubated for 4 hrs by rapid equilibrium dialysis method | Homo sapiens | 20 | ALA4321844 | cell-free format | Scientific Literature | |
9. | ALA4324217 | ADME | Clearance in iv dosed rat | Rattus norvegicus | 11 | ALA4321844 | organism-based format | Scientific Literature | |
10. | ALA4324218 | ADME | Unbound clearance in iv dosed rat | Rattus norvegicus | 11 | ALA4321844 | organism-based format | Scientific Literature |