# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4393045 | ADME | Binding affinity to PSMA in human LNCAP cells assessed as doxorubicin release in nucleus measured after 48 hrs | Homo sapiens | 1 | ALA4392830 | cell-based format | Scientific Literature | |
2. | ALA4393052 | ADME | Binding affinity to PSMA in human LNCAP cells assessed as doxorubicin release in nucleus measured after 40 milliseconds | Homo sapiens | 4 | ALA4392830 | cell-based format | Scientific Literature | |
3. | ALA4393056 | Functional | Cytotoxicity against PSMA-positive human LNCAP cells by MTT assay | Homo sapiens | 5 | ALA4392830 | cell-based format | Scientific Literature | |
4. | ALA4393057 | Functional | Cytotoxicity against PSMA-negative human PC3 cells by MTT assay | Homo sapiens | 5 | ALA4392830 | cell-based format | Scientific Literature | |
5. | ALA4393058 | Functional | Selectivity index, ratio of CC50 for PSMA-negative human PC3 cells to CC50 for PSMA-positive human LNCAP cells | Homo sapiens | 1 | ALA4392830 | assay format | Scientific Literature | |
6. | ALA4393061 | Toxicity | Toxicity in nu/nu mouse xenografted with PSMA-positive human PC3-PIP cells assessed as effect on food consumption at 4 mg/kg, ip per week for 3 weeks | Mus musculus | 1 | ALA4392830 | organism-based format | Scientific Literature | |
7. | ALA4393062 | Toxicity | Toxicity in nu/nu mouse xenografted with PSMA-positive human PC3-PIP cells assessed as body weight loss at 4 mg/kg, ip per week for 3 weeks | Mus musculus | 1 | ALA4392830 | organism-based format | Scientific Literature | |
8. | ALA4393063 | Functional | Antitumor activity against PSMA-positive human PC3-PIP cells xenografted in nu/nu mouse assessed as tumor growth inhibition at 4 mg/kg, ip per week for 3 weeks relative to control | Homo sapiens | 2 | ALA4392830 | organism-based format | Scientific Literature | |
9. | ALA4393064 | Physicochemical | Stability of the compound at pH 7.4 | 1 | ALA4392830 | small-molecule physicochemical format | Scientific Literature |