# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4353136 | Toxicity | Toxicity in BALB/c nu/nu mouse xenografted with human MV4-11 cells assessed as effect on body weight at 20 to 40 mg/kg, iv bid for 14 days | Mus musculus | 2 | ALA4350983 | organism-based format | Scientific Literature | |
2. | ALA4353138 | Binding | Inhibition of human FLT3 ITD mutant using EAIYAAPFAKKK peptide as substrate in presence of 33P-gamma ATP by hotspot kinase assay | Homo sapiens | 42 | ALA4350983 | single protein format | Scientific Literature | |
3. | ALA4353139 | Functional | Growth inhibition of human MV4-11 cells measured after 72 hrs by Celltiter-Glo assay | Homo sapiens | 27 | ALA4350983 | cell-based format | Scientific Literature | |
4. | ALA4353180 | ADME | Half-life in human liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | ALA4350983 | microsome format | Scientific Literature | |
5. | ALA4353181 | ADME | Half-life in rat liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4350983 | microsome format | Scientific Literature | |
6. | ALA4353182 | ADME | Intrinsic clearance in human liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 2 | ALA4350983 | microsome format | Scientific Literature | |
7. | ALA4353183 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM after 15 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4350983 | microsome format | Scientific Literature | |
8. | ALA4353251 | Functional | Antitumour activity against human MV4-11 cells xenografted in BALB/c nu/nu mouse assessed as tumour growth inhibition at 40 mg/kg, iv bid for 14 days and measured every 3 days by caliper method | Homo sapiens | 2 | ALA4350983 | organism-based format | Scientific Literature | |
9. | ALA4353253 | Functional | Antitumour activity against human MV4-11 cells xenografted in BALB/c nu/nu mouse assessed as tumour growth rate at 40 mg/kg, iv bid for 14 days measured every 3 days by vernier caliper method relative to control | Homo sapiens | 2 | ALA4350983 | organism-based format | Scientific Literature | |
10. | ALA4353330 | Functional | Antitumour activity against human MV4-11 cells xenografted in BALB/c nu/nu mouse assessed as inhibition of tumor weight at 40 mg/kg, iv bid for 14 days measured every 3 days by vernier caliper method relative to control | Homo sapiens | 2 | ALA4350983 | organism-based format | Scientific Literature |