# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4393309 | B | Inhibition of MERS-CoV papain-like protease using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and measured for 10 mins by fluorescence assay | Middle East respiratory syndrome-related coronavirus | 11 | ALA4392846 | single protein format | Scientific Literature | |
2. | ALA4393310 | B | Inhibition of MERS-CoV papain-like protease at 50 uM using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate preincubated for 5 mins followed by substrate addition and measured for 10 mins by fluorescence assay relative to control | Middle East respiratory syndrome-related coronavirus | 2 | ALA4392846 | single protein format | Scientific Literature | |
3. | ALA4393311 | B | Binding affinity to MERS-CoV papain-like protease assessed as association rate constant by SPR analysis | Middle East respiratory syndrome-related coronavirus | 2 | ALA4392846 | single protein format | Scientific Literature | |
4. | ALA4393312 | B | Binding affinity to MERS-CoV papain-like protease assessed as dissociation rate constant by SPR analysis | Middle East respiratory syndrome-related coronavirus | 2 | ALA4392846 | single protein format | Scientific Literature | |
5. | ALA4393313 | B | Binding affinity to MERS-CoV papain-like protease by SPR analysis | Middle East respiratory syndrome-related coronavirus | 8 | ALA4392846 | single protein format | Scientific Literature | |
6. | ALA4393314 | B | Competitive-inhibition of MERS-CoV papain-like protease using varying levels of Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate by Dixon-plot analysis | Middle East respiratory syndrome-related coronavirus | 2 | ALA4392846 | single protein format | Scientific Literature | |
7. | ALA4393316 | B | Ratio of Kd for MERS-CoV papain-like protease in presence of Z-Arg-Leu-Arg-Gly-Gly-AMC to Kd for MERS-CoV papain-like protease in absence of Z-Arg-Leu-Arg-Gly-Gly-AMC | Middle East respiratory syndrome-related coronavirus | 1 | ALA4392846 | single protein format | Scientific Literature | |
8. | ALA4393317 | B | Reversible inhibition of MERS-CoV papain-like protease assessed as recovery of enzyme activity at 125 times IC50 using Z-Arg-Leu-Arg-Gly-Gly-AMC as substrate incubated for 1 hr followed by 2-fold dilution and measured by fluorescence assay | Middle East respiratory syndrome-related coronavirus | 1 | ALA4392846 | single protein format | Scientific Literature | |
9. | ALA4393318 | B | Binding affinity to 15N-labelled His-tagged Apo-MRES-CoV papain-like protease by TROSY [1H-15N] spectroscopy | Middle East respiratory syndrome-related coronavirus | 1 | ALA4392846 | single protein format | Scientific Literature |