# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4357332 | Binding | Inhibition of human activated factor XI using pyro-Glu-Pro-Arg-pNA as substrate by spectrophotometry | Homo sapiens | 17 | ALA4354834 | single protein format | Scientific Literature | |
2. | ALA4357333 | Functional | Anticoagulant activity in human plasma assessed as concentration required to increase activated partial thromboplastin time by anticoagulant auto-analyser | Homo sapiens | 17 | ALA4354834 | cell-free format | Scientific Literature | |
3. | ALA4357334 | ADME | Metabolic stability in human liver microsomes assessed as half life | Homo sapiens | 17 | ALA4354834 | microsome format | Scientific Literature | |
4. | ALA4357335 | ADME | Permeability of the compound across apical side to basolateral side in human Caco2 cells | Homo sapiens | 17 | ALA4354834 | cell-based format | Scientific Literature | |
5. | ALA4357336 | ADME | Permeability of the compound across basolateral side to apical side in human Caco2 cells | Homo sapiens | 17 | ALA4354834 | cell-based format | Scientific Literature | |
6. | ALA4357337 | ADME | Efflux ratio of permeability from basolateral to apical over apical to basolateral side in human Caco2 cells | Homo sapiens | 11 | ALA4354834 | cell-based format | Scientific Literature | |
7. | ALA4357338 | ADME | Metabolic stability in rat liver microsomes assessed as half life | Rattus norvegicus | 9 | ALA4354834 | microsome format | Scientific Literature | |
8. | ALA4357339 | ADME | Clearance in rat at 0.70 mg/kg, iv or 1.40 mg/kg, po | Rattus norvegicus | 4 | ALA4354834 | organism-based format | Scientific Literature | |
9. | ALA4357340 | ADME | Half life in rat at 0.70 mg/kg, iv or 1.40 mg/kg, po | Rattus norvegicus | 4 | ALA4354834 | organism-based format | Scientific Literature | |
10. | ALA4357341 | ADME | Volume of distribution at steady state in rat at 0.70 mg/kg, iv or 1.40 mg/kg, po | Rattus norvegicus | 4 | ALA4354834 | organism-based format | Scientific Literature | |
11. | ALA4357342 | ADME | Oral bioavailability in rat at 1.40 mg/kg | Rattus norvegicus | 4 | ALA4354834 | organism-based format | Scientific Literature | |
12. | ALA4357343 | ADME | AUC in rat at 1.40 mg/kg, po | Rattus norvegicus | 4 | ALA4354834 | organism-based format | Scientific Literature | |
13. | ALA4357359 | ADME | Protein binding in rat | Rattus norvegicus | 7 | ALA4354834 | assay format | Scientific Literature |