| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4367995 | Binding | Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor expressed in CHO-K1 cell membranes incubated for 60 mins by microbeta scintillation counting method | Homo sapiens | 29 | ALA4364313 | cell-based format | Scientific Literature | |
| 2. | ALA4367996 | Binding | Displacement of [3H]-citalopram from SERT in rat cortex tissue incubated for 60 mins by microbeta scintillation counting method | Rattus norvegicus | 28 | ALA4364313 | assay format | Scientific Literature | |
| 3. | ALA4367997 | Binding | Displacement of [3H]ketanserin from human 5HT2A receptor expressed in HEK293 cells incubated for 1.5 hrs by Cheng-Prusoff analysis based microbeta scintillation counting method | Homo sapiens | 13 | ALA4364313 | cell-based format | Scientific Literature | |
| 4. | ALA4367998 | Binding | Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method | Homo sapiens | 13 | ALA4364313 | cell-based format | Scientific Literature | |
| 5. | ALA4367999 | Binding | Displacement of [3H]-5-CT from human 5HT7 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method | Homo sapiens | 13 | ALA4364313 | cell-based format | Scientific Literature | |
| 6. | ALA4368000 | Binding | Displacement of [3H]-raclopride from human D2 receptor expressed in HEK cells incubated for 1 hr by Cheng-Prusoff analysis based microbeta scintillation counting method | Homo sapiens | 13 | ALA4364313 | cell-based format | Scientific Literature | |
| 7. | ALA4368001 | Functional | Induction of hypothermia in CD-1 mouse assessed as change in body temperature at 5 mg/kg, ip treated for 30 mins and measured after 30 mins by thermometric method (Rvb = 0.2 to 0.5 deg C) | Mus musculus | 6 | ALA4364313 | organism-based format | Scientific Literature | |
| 8. | ALA4368002 | Functional | Induction of hypothermia in CD-1 mouse assessed as change in body temperature at 5 mg/kg, ip treated for 60 mins and measured after 30 mins by thermometric method (Rvb = 0.0 to 0.1 deg C) | Mus musculus | 6 | ALA4364313 | organism-based format | Scientific Literature | |
| 9. | ALA4368003 | Functional | Induction of hypothermia in CD-1 mouse assessed as change in body temperature at 5 mg/kg, ip treated for 90 mins and measured after 30 mins by thermometric method (Rvb = -0.1 to 0.1 deg C) | Mus musculus | 6 | ALA4364313 | organism-based format | Scientific Literature | |
| 10. | ALA4368004 | Functional | Induction of hypothermia in CD-1 mouse assessed as change in body temperature at 5 mg/kg, ip treated for 120 mins and measured after 30 mins by thermometric method (Rvb = 0.1 to 0.3 deg C) | Mus musculus | 6 | ALA4364313 | organism-based format | Scientific Literature | |
| 11. | ALA4368005 | Functional | Induction of hypothermia in CD-1 mouse assessed as change in body temperature at 20 mg/kg, ip treated for 30 mins and measured after 30 mins by thermometric method (Rvb = 0.2 to 0.5 deg C) | Mus musculus | 6 | ALA4364313 | organism-based format | Scientific Literature | |
| 12. | ALA4368006 | Functional | Induction of hypothermia in CD-1 mouse assessed as change in body temperature at 20 mg/kg, ip treated for 60 mins and measured after 30 mins by thermometric method (Rvb = 0.0 to 0.1 deg C) | Mus musculus | 6 | ALA4364313 | organism-based format | Scientific Literature | |
| 13. | ALA4368007 | Functional | Induction of hypothermia in CD-1 mouse assessed as change in body temperature at 20 mg/kg, ip treated for 90 mins and measured after 30 mins by thermometric method (Rvb = -0.1 to 0.1 deg C) | Mus musculus | 6 | ALA4364313 | organism-based format | Scientific Literature | |
| 14. | ALA4368008 | Functional | Induction of hypothermia in CD-1 mouse assessed as change in body temperature at 20 mg/kg, ip treated for 120 mins and measured after 30 mins by thermometric method (Rvb = 0.1 to 0.3 deg C) | Mus musculus | 6 | ALA4364313 | organism-based format | Scientific Literature | |
| 15. | ALA4368009 | Functional | Inhibition of 8-OH-DPAT-induced hypothermia in CD-1 mouse assessed change in body temperature at 20 mg/kg, ip pretreated for 45 mins followed by 8-OH-DPAT addition and measured after 15 mins by thermometric method (Rvb = -1.4 to -0.8 deg C) | Mus musculus | 5 | ALA4364313 | organism-based format | Scientific Literature | |
| 16. | ALA4368010 | Functional | Inhibition of 8-OH-DPAT-induced hypothermia in CD-1 mouse assessed change in body temperature at 20 mg/kg, ip pretreated for 45 mins followed by 8-OH-DPAT addition and measured after 30 mins by thermometric method (Rvb = -2.1 to -0.8 deg C) | Mus musculus | 5 | ALA4364313 | organism-based format | Scientific Literature | |
| 17. | ALA4368011 | Functional | Inhibition of 8-OH-DPAT-induced hypothermia in CD-1 mouse assessed change in body temperature at 20 mg/kg, ip pretreated for 45 mins followed by 8-OH-DPAT addition and measured after 45 mins by thermometric method (Rvb = -2.7 to -1.0 deg C) | Mus musculus | 5 | ALA4364313 | organism-based format | Scientific Literature | |
| 18. | ALA4368012 | Functional | Inhibition of 8-OH-DPAT-induced hypothermia in CD-1 mouse assessed change in body temperature at 20 mg/kg, ip pretreated for 45 mins followed by 8-OH-DPAT addition and measured after 60 mins by thermometric method (Rvb = -2.8 to -0.6 deg C) | Mus musculus | 5 | ALA4364313 | organism-based format | Scientific Literature | |
| 19. | ALA4368014 | ADME | Half life in human liver microsomes at 1 uM measured for 5 to 60 mins under shaking condition in presence of NADPH by LCMS analysis | Homo sapiens | 7 | ALA4364313 | microsome format | Scientific Literature |
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