# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4338949 | B | Inhibition of recombinant SMYD3 (unknown origin) transfected in human HEK293 cells assessed as reduction in MEKK3 methylation at >400 nM incubated for 24 hrs by cellular mechanistic assay relative to control | Homo sapiens | 1 | ALA4334548 | cell-based format | Scientific Literature | |
2. | ALA4338950 | B | Inhibition of recombinant N-terminal FLAG/His-tagged SMYD3 (unknown origin) expressed in baculovirus infected insect cells using 3H-SAM as substrate assessed as 3H-MEKK2 methylation incubated for 40 mins by scintillation proximity assay | Homo sapiens | 49 | ALA4334548 | cell-based format | Scientific Literature | |
3. | ALA4338951 | B | Inhibition of recombinant SMYD3 (unknown origin) transfected in human HEK293 cells assessed as reduction in MEKK2 methylation incubated for 24 hrs by cellular mechanistic assay | Homo sapiens | 49 | ALA4334548 | cell-based format | Scientific Literature | |
4. | ALA4338954 | B | Uncompetitive inhibition of SMYD3 (unknown origin) assessed as inhibitory constant incubated for 60 mins by Cheng-Prusoff equation analysis | Homo sapiens | 3 | ALA4334548 | single protein format | Scientific Literature | |
5. | ALA4338955 | B | Uncompetitive inhibition of SMYD3 (unknown origin) assessed as inhibitory constant incubated for 60 mins by Lineweaver-Burk plot analysis | Homo sapiens | 1 | ALA4334548 | single protein format | Scientific Literature | |
6. | ALA4338957 | B | Inhibition of recombinant SMYD3 in human A549 cells assessed as reduction in ERK1/2 phosphorylation at 30 uM preincubated for 72 hrs followed by incubated in serum free for 24 hrs by Western blot analysis | Homo sapiens | 3 | ALA4334548 | cell-based format | Scientific Literature | |
7. | ALA4338964 | A | AUC in Sprague-Dawley rat at 2 mg/kg, po | Rattus norvegicus | 8 | ALA4334548 | organism-based format | Scientific Literature | |
8. | ALA4338965 | A | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg | Rattus norvegicus | 7 | ALA4334548 | organism-based format | Scientific Literature | |
9. | ALA4338966 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po | Rattus norvegicus | 4 | ALA4334548 | organism-based format | Scientific Literature | |
10. | ALA4338967 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po | Rattus norvegicus | 4 | ALA4334548 | organism-based format | Scientific Literature | |
11. | ALA4338968 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv or 2 mg/kg, po | Rattus norvegicus | 4 | ALA4334548 | organism-based format | Scientific Literature |