| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4392309 | Binding | Inhibition of recombinant Cryptosporidium hominis TS-DHFR expressed in Escherichia coli PA414 assessed as reduction in DHFR steady state activity at 500 uM using [3',5',7,9-3H]-H2folate as substrate preincubated for 10 mins before NADPH addition for 5 mins followed by substrate addition and measured after 5 mins by NADPH based radiometric chemical quench assay relative to control | Cryptosporidium hominis | 33 | ALA4390681 | assay format | Scientific Literature | |
| 2. | ALA4392311 | Physicochemical | Solubility of the compound at >500 uM | 6 | ALA4390681 | small-molecule physicochemical format | Scientific Literature | ||
| 3. | ALA4392318 | Binding | Inhibition of recombinant Cryptosporidium hominis TS-DHFR expressed in Escherichia coli PA414 assessed as reduction in DHFR steady state activity using [3',5',7,9-3H]-H2folate as substrate preincubated for 10 mins before NADPH addition for 5 mins followed by substrate addition and measured after 5 mins by NADPH based radiometric chemical quench assay relative to control | Cryptosporidium hominis | 6 | ALA4390681 | assay format | Scientific Literature |
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