# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4349912 | Binding | Inverse agonist activity at GST-tagged RORgammat LBD (unknown origin) using fluorescein-D22 co-activator peptide as substrate incubated for 1 hr by TR-FRET assay | Homo sapiens | 46 | ALA4346735 | single protein format | Scientific Literature | |
2. | ALA4349913 | Binding | Transactivation of recombinant GAL4-DBD fused RORgammat LBD (unknown origin) expressed in HEK293T cells incubated for 18 to 24 hrs by dual-Glo luciferase assay | Homo sapiens | 44 | ALA4346735 | cell-based format | Scientific Literature | |
3. | ALA4349921 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 44 | ALA4346735 | microsome format | Scientific Literature | |
4. | ALA4349922 | ADME | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 44 | ALA4346735 | microsome format | Scientific Literature | |
5. | ALA4349923 | ADME | Inhibition of CYP2C19 in human liver microsomes using (S)-mephenytoin as substrate preincubated for 5 mins followed by NADPH addition measured after 40 mins by LC-MS/MS analysis | Homo sapiens | 44 | ALA4346735 | microsome format | Scientific Literature | |
6. | ALA4349924 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 44 | ALA4346735 | microsome format | Scientific Literature | |
7. | ALA4349925 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 44 | ALA4346735 | microsome format | Scientific Literature | |
8. | ALA4349926 | ADME | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate preincubated for 5 mins followed by NADPH addition measured after 10 mins by LC-MS/MS analysis | Homo sapiens | 44 | ALA4346735 | microsome format | Scientific Literature | |
9. | ALA4349927 | Physicochemical | Solubility of the compound at pH 2.1 | 44 | ALA4346735 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4349928 | Physicochemical | Solubility of the compound at pH 4 | 44 | ALA4346735 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4349929 | Physicochemical | Solubility of the compound at pH 7.4 | 44 | ALA4346735 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4349932 | Binding | Transrepression of RORgammat in Balb/c mouse splenocytes assessed as inhibition of anti-CD3/anti-CD28 stimulated IL-17 gene expression at 0.3 uM measured after 24 hrs in presence of anti-CD3/anti-CD28 | Mus musculus | 4 | ALA4346735 | cell-based format | Scientific Literature | |
13. | ALA4349933 | Binding | Transrepression of RORgammat in Balb/c mouse splenocytes assessed as inhibition of anti-CD3/anti-CD28 stimulated IL-17 gene expression at 3 uM measured after 24 hrs in presence of anti-CD3/anti-CD28 | Mus musculus | 4 | ALA4346735 | cell-based format | Scientific Literature | |
14. | ALA4349934 | Binding | Transrepression of RORgammat in Balb/c mouse splenocytes assessed as inhibition of anti-CD3/anti-CD28 stimulated IL-17 gene expression at 30 uM measured after 24 hrs in presence of anti-CD3/anti-CD28 | Mus musculus | 4 | ALA4346735 | cell-based format | Scientific Literature | |
15. | ALA4349960 | ADME | Cmax in mouse at 10 mg/kg, po | Mus musculus | 6 | ALA4346735 | organism-based format | Scientific Literature | |
16. | ALA4349961 | ADME | Tmax in mouse at 10 mg/kg, po | Mus musculus | 6 | ALA4346735 | organism-based format | Scientific Literature | |
17. | ALA4349962 | ADME | AUC (0 to 24 hrs) in mouse at 10 mg/kg, po | Mus musculus | 6 | ALA4346735 | organism-based format | Scientific Literature | |
18. | ALA4349963 | ADME | Volume of distribution at steady state in mouse at 3 mg/kg, iv | Mus musculus | 6 | ALA4346735 | organism-based format | Scientific Literature | |
19. | ALA4349964 | ADME | Clearance in mouse at 3 mg/kg, iv | Mus musculus | 6 | ALA4346735 | organism-based format | Scientific Literature | |
20. | ALA4349965 | ADME | Half life in mouse at 3 mg/kg, iv | Mus musculus | 6 | ALA4346735 | organism-based format | Scientific Literature |