# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4385176 | Functional | Protection against cisplatin-induced cytotoxicity in rat NRK-52E cells assessed as increase in cell viability at 20 uM after 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA4382270 | cell-based format | Scientific Literature | |
2. | ALA4385177 | Functional | Protection against cisplatin-induced cytotoxicity in rat NRK-52E cells assessed as improvement in morphological changes after 24 hrs by microscopic analysis | Rattus norvegicus | 1 | ALA4382270 | cell-based format | Scientific Literature | |
3. | ALA4385178 | Functional | Protection against cisplatin-induced cytotoxicity in rat NRK-52E cells assessed as increase in cell viability after 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA4382270 | cell-based format | Scientific Literature | |
4. | ALA4385179 | ADME | Cytotoxicity against rat NRK-52E cells assessed as effect on cell viability at 1 to 50 uM after 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA4382270 | cell-based format | Scientific Literature | |
5. | ALA4385180 | Functional | Protection against cisplatin-induced cell damage in rat NRK-52E cells assessed as reduction in reactive oxygen species generation at 10 uM after 24 hrs by DCF staining based fluorescence microscopic analysis | Rattus norvegicus | 1 | ALA4382270 | cell-based format | Scientific Literature | |
6. | ALA4385181 | Functional | Protection against cisplatin-induced cell damage in rat NRK-52E cells assessed as reversal of mitochondrial membrane potential loss at 10 uM after 24 hrs by JC1 staining based fluorescence microscopic analysis | Rattus norvegicus | 1 | ALA4382270 | cell-based format | Scientific Literature | |
7. | ALA4385182 | Functional | Protection against cisplatin-induced apoptosis in rat NRK-52E cells assessed as reduction in cleaved caspase-3 level at 10 uM after 24 hrs by Western blot analysis | Rattus norvegicus | 1 | ALA4382270 | cell-based format | Scientific Literature | |
8. | ALA4385183 | Functional | Protection against cisplatin-induced acute liver injury in Sprague-Dawley rat assessed as reduction in cleaved caspase-3 level in kidneys at 1 mg/kg pretreated for 24 hrs followed by cisplatin challenge and subsequent qd dosing for 5 days measured 7 days post cisplatin challenge by Western blot analysis | Rattus norvegicus | 1 | ALA4382270 | organism-based format | Scientific Literature | |
9. | ALA4385184 | Functional | Protection against cisplatin-induced acute liver injury in Sprague-Dawley rat assessed as reversal of histopathological changes in kidney at 1 mg/kg pretreated for 24 hrs followed by cisplatin challenge and subsequent qd dosing for 5 days measured 7 days post cisplatin challenge by H and E staining based light microscopic analysis | Rattus norvegicus | 1 | ALA4382270 | organism-based format | Scientific Literature | |
10. | ALA4385185 | Functional | Protection against cisplatin-induced acute liver injury in Sprague-Dawley rat assessed as restoration of serum BUN levels at 1 mg/kg pretreated for 24 hrs followed by cisplatin challenge and subsequent qd dosing for 5 days measured 7 days post cisplatin challenge | Rattus norvegicus | 1 | ALA4382270 | organism-based format | Scientific Literature | |
11. | ALA4385186 | Functional | Protection against cisplatin-induced acute liver injury in Sprague-Dawley rat assessed as restoration of serum creatinine levels at 1 mg/kg pretreated for 24 hrs followed by cisplatin challenge and subsequent qd dosing for 5 days measured 7 days post cisplatin challenge | Rattus norvegicus | 1 | ALA4382270 | organism-based format | Scientific Literature | |
12. | ALA4385187 | Toxicity | Renal toxicity in Sprague-Dawley rat assessed as histopathological changes in kidney at 1 mg/kg administered once daily for 6 days by H and E staining based light microscopic analysis | Rattus norvegicus | 1 | ALA4382270 | organism-based format | Scientific Literature | |
13. | ALA4385188 | Toxicity | Renal toxicity in Sprague-Dawley rat assessed as change in serum BUN levels at 1 mg/kg administered once daily for 6 days | Rattus norvegicus | 1 | ALA4382270 | organism-based format | Scientific Literature | |
14. | ALA4385189 | Toxicity | Renal toxicity in Sprague-Dawley rat assessed as change in serum creatinine levels at 1 mg/kg administered once daily for 6 days | Rattus norvegicus | 1 | ALA4382270 | organism-based format | Scientific Literature |