| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4393072 | F | Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as reduction in calcium mobilization incubated for 142 secs prior to glutamate addition for 120 secs followed by L-AP4 addition and measured after 40 secs by Fluo-4 AM dye based fluorescence assay | Rattus norvegicus | 39 | ALA4392832 | cell-based format | Scientific Literature | |
| 2. | ALA4393073 | F | Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells co-expressing Galpha15 assessed as minimum L-AP4 response by measuring reduction in calcium mobilization incubated for 142 secs prior to glutamate addition for 120 secs followed by L-AP4 addition and measured after 40 secs by Fluo-4 AM dye based fluorescence assay relative to L-AP4 alone | Rattus norvegicus | 22 | ALA4392832 | cell-based format | Scientific Literature | |
| 3. | ALA4393074 | A | Protein binding in rat plasma assessed as unbound fraction at 5 uM measured after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 2 | ALA4392832 | cell-free format | Scientific Literature | |
| 4. | ALA4393075 | A | Brain to plasma permeability coefficient, Kp of compound in rat | Rattus norvegicus | 2 | ALA4392832 | cell-free format | Scientific Literature | |
| 5. | ALA4393076 | A | Unbound brain to plasma concentration ratio in rat | Rattus norvegicus | 2 | ALA4392832 | cell-free format | Scientific Literature | |
| 6. | ALA4393077 | A | Protein binding in rat brain assessed as unbound fraction at 5 uM measured after 6 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4392832 | tissue-based format | Scientific Literature | |
| 7. | ALA4393078 | A | Total drug level in Sprague-Dawley rat brain at 0.2 mg/kg, iv via cassette dosing measured after 0.25 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4392832 | organism-based format | Scientific Literature | |
| 8. | ALA4393079 | A | Free drug level in Sprague-Dawley rat brain at 0.2 mg/kg, iv via cassette dosing measured after 0.25 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4392832 | organism-based format | Scientific Literature | |
| 9. | ALA4393080 | B | Negative allosteric modulation of mGlu1 receptor (unknown origin) | Homo sapiens | 1 | ALA4392832 | single protein format | Scientific Literature | |
| 10. | ALA4393081 | B | Negative allosteric modulation of mGlu2 receptor (unknown origin) | Homo sapiens | 1 | ALA4392832 | single protein format | Scientific Literature | |
| 11. | ALA4393082 | B | Negative allosteric modulation of mGlu3 receptor (unknown origin) | Homo sapiens | 1 | ALA4392832 | single protein format | Scientific Literature | |
| 12. | ALA4393083 | B | Negative allosteric modulation of mGlu4 receptor (unknown origin) | Homo sapiens | 1 | ALA4392832 | single protein format | Scientific Literature | |
| 13. | ALA4393084 | B | Negative allosteric modulation of mGlu5 receptor (unknown origin) | Homo sapiens | 1 | ALA4392832 | single protein format | Scientific Literature | |
| 14. | ALA4393085 | B | Negative allosteric modulation of mGlu6 receptor (unknown origin) | Homo sapiens | 1 | ALA4392832 | single protein format | Scientific Literature | |
| 15. | ALA4393086 | B | Negative allosteric modulation of mGlu8 receptor (unknown origin) | Homo sapiens | 1 | ALA4392832 | single protein format | Scientific Literature | |
| 16. | ALA5106321 | F | Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mobilization assay | Rattus norvegicus | 23 | ALA5104167 | cell-based format | Scientific Literature | |
| 17. | ALA5106322 | F | Negative allosteric modulation of rat mGlu7 in HEK cells expressing Galpha15 assessed as inhibition of L-AP4-induced response measured by calcium mobilization assay relative to control | Rattus norvegicus | 22 | ALA5104167 | cell-based format | Scientific Literature | |
| 18. | ALA5106323 | B | Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay | Homo sapiens | 16 | ALA5104167 | assay format | Scientific Literature | |
| 19. | ALA5106324 | B | Negative allosteric modulation of mGlu7 (unknown origin) in cells expressing G protein-regulated inwardly rectifying potassium channels (GIRKs) assessed as inhibition of L-AP4-induced response measured by thallium flux assay relative to control | Homo sapiens | 22 | ALA5104167 | assay format | Scientific Literature | |
| 20. | ALA5106325 | A | Plasma protein binding in rat | Rattus norvegicus | 3 | ALA5104167 | cell-free format | Scientific Literature |
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