| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4383292 | Binding | Inhibition of Enterococcus faecalis JH2-2 C-terminal 6His-tagged DdlB expressed in Escherichia coli LMG194 preincubated for 30 mins followed by substrate addition and measured after 20 mins by Biomol Green reagent assay | Enterococcus faecalis | 22 | ALA4382202 | assay format | Scientific Literature | |
| 2. | ALA4383293 | Binding | Inhibition of Enterococcus faecalis JH2-2 C-terminal 6His-tagged DdlB expressed in Escherichia coli LMG194 at 10 uM preincubated for 30 mins followed by substrate addition and measured after 20 mins by Biomol Green reagent assay relative to control | Enterococcus faecalis | 24 | ALA4382202 | assay format | Scientific Literature | |
| 3. | ALA4383297 | Functional | Antibacterial activity against Staphylococcus aureus ATCC 25923 after 18 to 24 hrs by microdilution assay | Staphylococcus aureus | 42 | ALA4382202 | organism-based format | Scientific Literature | |
| 4. | ALA4383298 | Functional | Antibacterial activity against Enterococcus faecalis ATCC 29212 after 18 to 24 hrs by microdilution assay | Enterococcus faecalis | 42 | ALA4382202 | organism-based format | Scientific Literature | |
| 5. | ALA4383299 | Functional | Antibacterial activity against vancomycin-resistant Enterococcus faecalis BM 4390 after 18 to 24 hrs by microdilution assay | Enterococcus faecalis | 26 | ALA4382202 | organism-based format | Scientific Literature | |
| 6. | ALA4383300 | Functional | Antibacterial activity against vancomycin-resistant Enterococcus faecalis JH2-2::C1 after 18 to 24 hrs by microdilution assay | Enterococcus faecalis | 26 | ALA4382202 | organism-based format | Scientific Literature | |
| 7. | ALA4383301 | Functional | Antibacterial activity against vancomycin-resistant Enterococcus faecalis BM 4575 clinical isolate after 18 to 24 hrs by microdilution assay | Enterococcus faecalis | 26 | ALA4382202 | organism-based format | Scientific Literature | |
| 8. | ALA4383302 | Functional | Antibacterial activity against methicillin and vancomycin intermediate resistant Staphylococcus aureus MU50 after 18 to 24 hrs by microdilution assay | Staphylococcus aureus | 26 | ALA4382202 | organism-based format | Scientific Literature | |
| 9. | ALA4383303 | Functional | Antibacterial activity against methicillin and linezolid resistant Staphylococcus aureus NRS 119 clinical isolate after 18 to 24 hrs by microdilution assay | Staphylococcus aureus | 26 | ALA4382202 | organism-based format | Scientific Literature | |
| 10. | ALA4383304 | Functional | Antibacterial activity against community-acquired methicillin and erythromycin resistant Staphylococcus aureus SA 325 after 18 to 24 hrs by microdilution assay | Staphylococcus aureus | 26 | ALA4382202 | organism-based format | Scientific Literature | |
| 11. | ALA4383305 | Functional | Antibacterial activity against hospital-acquired methicillin/ciprofloxacin/moxifloxacin resistant Staphylococcus aureus SA 481 after 18 to 24 hrs by microdilution assay | Staphylococcus aureus | 26 | ALA4382202 | organism-based format | Scientific Literature | |
| 12. | ALA4383306 | Functional | Antibacterial activity against hospital-acquired methicillin and vacomycin resistant Staphylococcus aureus VRS-1 after 18 to 24 hrs by microdilution assay | Staphylococcus aureus | 26 | ALA4382202 | organism-based format | Scientific Literature | |
| 13. | ALA4383307 | Functional | Bactericidal activity against Staphylococcus aureus ATCC 25923 assessed as reduction of bacterial load at 2 to 5 times MIC after 24 hrs by time kill assay | Staphylococcus aureus | 1 | ALA4382202 | organism-based format | Scientific Literature | |
| 14. | ALA4383308 | Binding | Inhibition of Ddl in Staphylococcus aureus ATCC 25923 assessed as increase in [D-Ala]/[D-Ala-D-Ala] ratio at 2 times MIC after 30 mins by LC-MS/MS analysis | Staphylococcus aureus | 1 | ALA4382202 | assay format | Scientific Literature | |
| 15. | ALA4383309 | ADME | Cytotoxicity against human THP1 cells assessed as decrease in cell viability at 1 to 5 times MIC after 24 hrs by trypan blue exclusion assay relative to control | Homo sapiens | 1 | ALA4382202 | cell-based format | Scientific Literature | |
| 16. | ALA4383310 | Binding | Inhibition of human recombinant ACE using Abz-FRK(Dnp)-P-OH as substrate after 30 mins by fluorimetric analysis | Homo sapiens | 1 | ALA4382202 | single protein format | Scientific Literature | |
| 17. | ALA4383311 | Binding | Displacement of [3H]8-OH-DPAT from recombinant human 5-HT1A receptor after 60 mins by scintillation counting analysis | Homo sapiens | 1 | ALA4382202 | single protein format | Scientific Literature | |
| 18. | ALA4383312 | Binding | Inhibition of human recombinant acetylcholinesterase using acetylthiocholine as substrate after 30 mins by spectrophotometric analysis | Homo sapiens | 1 | ALA4382202 | single protein format | Scientific Literature | |
| 19. | ALA4383313 | Binding | Inhibition of human recombinant Arg1 using L-arginine as substrate after 5 mins in presence of [guanidino-14C]-L-arginine by liquid scintillation counting analysis | Homo sapiens | 1 | ALA4382202 | single protein format | Scientific Literature | |
| 20. | ALA4383314 | Binding | Inhibition of Bacillus cereus beta-lactamase using nitrocefin as substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by spectrophotometric analysis | Bacillus cereus | 1 | ALA4382202 | assay format | Scientific Literature |
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