# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4406523 | Binding | Antagonist activity at human Gi/o-coupled ADRA2C expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment at 10 uM measured after 120 mins by beta-galactosidase based PathHunter assay relative to control | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
2. | ALA4406524 | Binding | Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 112 | ALA4402608 | cell-based format | Scientific Literature | |
3. | ALA4406525 | ADME | Antagonist activity at human PK1-tagged Gq-coupled ADRA1B expressed in CHOK1 cells assessed as inhibition of 7alpha,25-ihydroxycholesterol-induced beta-arrestin recruitment at 10 uM measured after 120 mins by beta-galactosidase based PathHunter assay relative to control | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
4. | ALA4406526 | ADME | Agonist activity at human D2R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 110 | ALA4402608 | cell-based format | Scientific Literature | |
5. | ALA4406527 | ADME | Antagonist activity at human D2R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 110 | ALA4402608 | cell-based format | Scientific Literature | |
6. | ALA4406529 | Binding | Displacement of [3H]-methylspiperon from human D3R expressed in HEK293 cell membranes measured after 90 mins in EBSS buffer by topcount assay | Homo sapiens | 4 | ALA4402608 | cell-based format | Scientific Literature | |
7. | ALA4406531 | Binding | Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay relative to dopamine | Homo sapiens | 109 | ALA4402608 | cell-based format | Scientific Literature | |
8. | ALA4406532 | ADME | Agonist activity at human D2R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay relative to dopamine | Homo sapiens | 109 | ALA4402608 | cell-based format | Scientific Literature | |
9. | ALA4406533 | ADME | Antagonist activity at human D2R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 mins by beta-galactosidase based PathHunter assay relative to sulpiride | Homo sapiens | 109 | ALA4402608 | cell-based format | Scientific Literature | |
10. | ALA4406534 | ADME | Agonist activity at Gs-coupled human D1R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
11. | ALA4406535 | ADME | Agonist activity at Gs-coupled human D5R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
12. | ALA4406536 | ADME | Agonist activity at Gi/Go-coupled human D4R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
13. | ALA4406537 | ADME | Antagonist activity at Gs-coupled human D1R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
14. | ALA4406538 | ADME | Antagonist activity at Gs-coupled human D5R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
15. | ALA4406539 | ADME | Antagonist activity at Gi/Go-coupled human D4R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 mins by beta-galactosidase based PathHunter assay | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
16. | ALA4406540 | Binding | Agonist activity at RLuc8-fused human D3R expressed in HEK293 cells co-expressing N-terminal Venus-tagged beta-arrestin2 and GRK3 assessed as induction of beta-arrestin2 recruitment measured after 5 mins in presence of coelenterazine H by BRET assay | Homo sapiens | 3 | ALA4402608 | cell-based format | Scientific Literature | |
17. | ALA4406541 | Binding | Selectivity ratio of EC50 for agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment by beta-galactosidase based PathHunter assay to EC50 for agonist activity at RLuc8-fused human D3R expressed in HEK293 cells co-expressing N-terminal Venus-tagged beta-arrestin2 and GRK3 assessed as induction of beta-arrestin2 recruitment by BRET assay | Homo sapiens | 1 | ALA4402608 | cell-based format | Scientific Literature | |
18. | ALA4406542 | Binding | Agonist activity at RLuc8-fused Go-coupled human D3R expressed in HEK293 cells untagged beta1 and mVenus-tagged gamma2 measured after 5 mins in presence of coelenterazine H by BRET assay | Homo sapiens | 2 | ALA4402608 | cell-based format | Scientific Literature | |
19. | ALA4406543 | Functional | Agonist activity at human D3R expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production measured after 5 mins in presence of beta-adrenergic blocker propranolol and coelenterazine H by CAMYEL BRET assay | Homo sapiens | 2 | ALA4402608 | cell-based format | Scientific Literature | |
20. | ALA4406544 | Binding | Agonist activity at human D3R stably expressed in CHOK1 cells assessed as increase in ERK1/2 phosphorylation measured after 15 mins by AlphaScreen surefire assay | Homo sapiens | 2 | ALA4402608 | cell-based format | Scientific Literature |