#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4414022	Binding	Inhibition of SHP2 in human KYSE520 cells assessed as reduction in ERK phosphorylation after 2 hrs by SureFire p-ERK assay	Homo sapiens	15	ALA4411331	cell-based format	Scientific Literature
2.	ALA4414023	Binding	Inhibition of human 6His-tagged SHP2 (1 to 525 residues) expressed in Escherichia coli BL21 Star (DE3) using DiFMUP as surrogate substrate as preincubated for 30 to 60 mins followed by substrate addition and measured after 30 mins bpV-based fluorescence assay	Homo sapiens	16	ALA4411331	assay format	Scientific Literature
3.	ALA4414024	Functional	Antiproliferative activity against human KYSE520 cells added 24 hrs after cell plating and measured on day 5 by Celltiter-Glo assay	Homo sapiens	15	ALA4411331	cell-based format	Scientific Literature
4.	ALA4414026	Binding	Inhibition of human ERG	Homo sapiens	11	ALA4411331	single protein format	Scientific Literature
5.	ALA4414027	ADME	Apparent permeability across apical to basolateral side in human Caco2 cells	Homo sapiens	3	ALA4411331	cell-based format	Scientific Literature
6.	ALA4414028	ADME	Intrinsic clearance in rat liver microsomes	Rattus norvegicus	3	ALA4411331	microsome format	Scientific Literature
7.	ALA4414029	ADME	Half life in rat liver microsomes	Rattus norvegicus	3	ALA4411331	microsome format	Scientific Literature
8.	ALA4414030	ADME	Dose normalized AUC in rat at 1 mg/kg, po	Rattus norvegicus	2	ALA4411331	organism-based format	Scientific Literature
9.	ALA4414031	ADME	Oral bioavailability in rat at 1 mg/kg	Rattus norvegicus	2	ALA4411331	organism-based format	Scientific Literature
10.	ALA4414037	ADME	Intrinsic clearance in mouse liver microsomes	Mus musculus	1	ALA4411331	microsome format	Scientific Literature
11.	ALA4414038	ADME	Half life in mouse liver microsomes	Mus musculus	1	ALA4411331	microsome format	Scientific Literature
12.	ALA4414039	Physicochemical	Aqueous solubility of the compound in 6.8 pH buffer		2	ALA4411331	small-molecule physicochemical format	Scientific Literature
13.	ALA4414040	ADME	Efflux ratio of apparent permeability in human Caco2 cells	Homo sapiens	1	ALA4411331	cell-based format	Scientific Literature
14.	ALA4414041	Functional	Antiproliferative activity against human Detroit 562 cells after 24 hrs by Celltiter-Glo assay	Homo sapiens	4	ALA4411331	cell-based format	Scientific Literature
15.	ALA4414042	ADME	Drug uptake in human Detroit 562 cells xenografted NU/NU mouse at 20 to 80 mg/kg, po BID	Mus musculus	1	ALA4411331	organism-based format	Scientific Literature
16.	ALA4414043	Functional	In vivo inhibition of SHP2 in human Detroit 562 cells xenografted in NU/NU mouse assessed as reduction in DUSP6 mRNA levels at 20 to 80 mg/kg, po administered BID and measured after 3 hrs by qPCR analysis	Mus musculus	1	ALA4411331	organism-based format	Scientific Literature
17.	ALA4414044	Functional	Antitumor activity against human Detroit 562 cells xenografted in NU/NU mouse assessed as reduction in tumor volume at 20 to 80 mg/kg, po administered BID and measured after 21 days	Homo sapiens	1	ALA4411331	organism-based format	Scientific Literature
18.	ALA4414045	Functional	Antitumor activity against human Detroit 562 cells xenografted in NU/NU mouse assessed as tumor stasis at 40 mg/kg, po administered BID and measured after 21 days relative to control	Homo sapiens	1	ALA4411331	organism-based format	Scientific Literature
19.	ALA4414046	Functional	Antitumor activity against human Detroit 562 cells xenografted in NU/NU mouse assessed as tumor regression at 80 mg/kg, po administered BID and measured after 14 days post dose relative to control	Homo sapiens	1	ALA4411331	organism-based format	Scientific Literature
20.	ALA4414050	ADME	Clearance in rat	Rattus norvegicus	1	ALA4411331	assay format	Scientific Literature