# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4329743 | B | Inhibition of human PMN leukocytes MPO chlorination activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured for 15 mins in presence of NaCl by aminophenyl fluorescein based assay | Homo sapiens | 3 | assay format | Scientific Literature | ||
2. | ALA4329744 | B | Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured for 15 mins by amplex red reagent based assay | Homo sapiens | 25 | assay format | Scientific Literature | ||
3. | ALA4329747 | A | AUC in mouse at 3 mg/kg, po after 8 hrs | Mus musculus | 3 | organism-based format | Scientific Literature | ||
4. | ALA4329749 | B | Inhibition of human EPX bromination activity assessed as reduction in H2O2 catalyzed 3-bromo tyrosine formation from tyrosine and potassium bromide preincubated for 10 mins followed by tyrosine/potassium bromide/H2O2 addition measured after 15 mins by RP-UPLC analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
5. | ALA4329750 | B | Inhibition of human TPO assessed as reduction in H2O2 catalyzed 3,5-iodo tyrosine formation from 3-iodotyrosine and potassium iodide preincubated for 10 mins followed by tyrosine/potassium bromide/H2O2 addition measured after 15 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
6. | ALA4329751 | B | Inhibition of human LPO assessed as reduction in H2O2 catalyzed 3,5-iodo tyrosine formation from 3-iodotyrosine and potassium iodide preincubated for 10 mins followed by tyrosine/potassium bromide/H2O2 addition measured after 15 mins | Homo sapiens | 2 | single protein format | Scientific Literature | ||
7. | ALA4329752 | A | Protein binding in human plasma | Homo sapiens | 2 | cell-free format | Scientific Literature | ||
8. | ALA4329753 | A | Protein binding in mouse plasma | Mus musculus | 2 | cell-free format | Scientific Literature | ||
9. | ALA4329754 | A | Cmax in mouse at 3 mg/kg, po | Mus musculus | 2 | organism-based format | Scientific Literature | ||
10. | ALA4329755 | B | Irreversible inhibition of human PMN leukocytes MPO peroxidation activity at IC90 using H2O2 as substrate preincubated for 20 mins followed by 100 fold compound dilution measured for 1 hr by amplex red reagent based assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
11. | ALA4329756 | B | Reversible inhibition of human PMN leukocytes MPO chlorination activity at IC90 using H2O2 as substrate preincubated for 20 mins followed by 100 fold compound dilution measured for 1 hr in presence of NaCl by aminophenyl fluorescein based assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
12. | ALA4329757 | B | Substrate activity at human PMN leukocytes MPO at 60 nM in presence of NaCl by stopped flow assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
13. | ALA4329758 | B | Substrate activity at human PMN leukocytes MPO at 60 nM in absence of NaCl by stopped flow assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
14. | ALA4329761 | F | In vivo inhibition of PMA-stimulated MPO in human MPO transgenic mouse model of acute inflammation assessed as reduction in hypochlorous acid production in blood administered orally 20 mins prior to PMA stimulation and measured after 2 mins by luminol chemiluminescence assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
15. | ALA4329762 | F | In vivo inhibition of TPO in mouse model of acute inflammation at 10 to 30 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
16. | ALA4329763 | F | In vivo inhibition of PMA-stimulated MPO in human MPO transgenic mouse model of acute inflammation assessed as reduction in hypochlorous acid production in blood at 10 mg/kg, po administered 20 mins prior to PMA stimulation and measured after 2 mins by luminol chemiluminescence assay relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
17. | ALA4329764 | F | In vivo inhibition of PMA-stimulated MPO in human MPO transgenic mouse model of acute inflammation assessed as reduction in hypochlorous acid production in blood at 30 mg/kg, po administered 20 mins prior to PMA stimulation and measured after 2 mins by luminol chemiluminescence assay relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
18. | ALA4329765 | A | Plasma concentration in human MPO transgenic mouse model of PMA-induced acute inflammation at 10 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature | ||
19. | ALA4329766 | A | Plasma concentration in human MPO transgenic mouse model of PMA-induced acute inflammation at 30 mg/kg, po | Mus musculus | 1 | organism-based format | Scientific Literature |