# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4345520 | ADME | Inhibition of recombinant human carbonic anhydrase 1 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | Homo sapiens | 8 | ALA4342501 | single protein format | Scientific Literature | |
2. | ALA4345521 | ADME | Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | Homo sapiens | 8 | ALA4342501 | single protein format | Scientific Literature | |
3. | ALA4345522 | Binding | Inhibition of Sulfurihydrogenibium yellowstonense alpha carbonic anhydrase incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | Sulfurihydrogenibium yellowstonense | 8 | ALA4342501 | assay format | Scientific Literature | |
4. | ALA4345523 | Binding | Inhibition of Vibrio cholerae alpha carbonic anhydrase incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | Vibrio cholerae | 8 | ALA4342501 | assay format | Scientific Literature | |
5. | ALA4345524 | Binding | Inhibition of Vibrio cholerae beta carbonic anhydrase incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | Vibrio cholerae | 8 | ALA4342501 | assay format | Scientific Literature | |
6. | ALA4345525 | Binding | Inhibition of Malassezia globosa beta carbonic anhydrase incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | Malassezia globosa | 8 | ALA4342501 | assay format | Scientific Literature | |
7. | ALA4345526 | Binding | Inhibition of Cryptococcus neoformans beta carbonic anhydrase incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | Cryptococcus neoformans | 8 | ALA4342501 | assay format | Scientific Literature | |
8. | ALA4345527 | Binding | Inhibition of Leishmania donovani beta carbonic anhydrase incubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay | Leishmania donovani | 8 | ALA4342501 | assay format | Scientific Literature | |
9. | ALA4345530 | Functional | Antileishmanial activity against Leishmania donovani axenic amastigotes assessed as reduction in parasite growth measured after 24 hrs by propidium iodide staining based flow cytometric method | Leishmania donovani | 8 | ALA4342501 | organism-based format | Scientific Literature | |
10. | ALA4345531 | ADME | Cytotoxicity against human THP1 cells assessed as reduction in cell viability measured after 24 hrs by propidium iodide staining based flow cytometry | Homo sapiens | 8 | ALA4342501 | cell-based format | Scientific Literature | |
11. | ALA4345532 | Toxicity | Selectivity index, ratio of IC50 for human THP1 cells to IC50 for antileishmanial activity against Leishmania donovani axenic amastigotes | 8 | ALA4342501 | assay format | Scientific Literature | ||
12. | ALA4345533 | Functional | Antileishmanial activity against Leishmania donovani amastigotes infected in human THP1 cells assessed as reduction in parasite infection at 3 uM measured after 48 hrs by GFP-reporter based flow cytometric method | Leishmania donovani | 5 | ALA4342501 | organism-based format | Scientific Literature | |
13. | ALA4813207 | Binding | Inhibition of recombinant human CA 1 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay | Homo sapiens | 8 | ALA4811284 | single protein format | Scientific Literature | |
14. | ALA4813208 | Binding | Inhibition of recombinant human CA2 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay | Homo sapiens | 8 | ALA4811284 | single protein format | Scientific Literature | |
15. | ALA4813209 | Binding | Inhibition of recombinant human CA4 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay | Homo sapiens | 8 | ALA4811284 | single protein format | Scientific Literature | |
16. | ALA4813210 | Binding | Inhibition of recombinant human CA7 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay | Homo sapiens | 8 | ALA4811284 | single protein format | Scientific Literature | |
17. | ALA4813211 | Binding | Inhibition of recombinant human CA9 preincubated for 15 mins by measured for 10 to 100 secs by phenol red dye based stopped flow CO2 hydration assay | Homo sapiens | 8 | ALA4811284 | single protein format | Scientific Literature | |
18. | ALA4813212 | Binding | Selectivity ratio, ratio of Ki of recombinant human CA2 to Ki of recombinant human CA9 | Homo sapiens | 8 | ALA4811284 | assay format | Scientific Literature |