# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4339112 | Binding | Inhibition of human N-terminal GST-tagged IDO1 expressed in Escherichia coli Rosetta(DE3) pLysS using L-tryptophan as substrate measured after 1 hr by fluorescence assay | Homo sapiens | 26 | ALA4334553 | assay format | Scientific Literature | |
2. | ALA4339113 | Binding | Inhibition of IDO1 in interferon-gamma-induced human SKOV3 cells assessed as N-formylkynurenine formation using L-tryptophan as substrate measured after 24 hrs by fluorescence assay | Homo sapiens | 26 | ALA4334553 | assay format | Scientific Literature | |
3. | ALA4339116 | ADME | Stability assessed as recombinant UGT1A9 (unknown origin) mediated compound glucuronidation by measuring half-life at 1 uM incubated in water bath by shaking at 37 degree C measured upto 60 mins in presence of UDPGA by LC-MS/MS analysis | Homo sapiens | 23 | ALA4334553 | single protein format | Scientific Literature | |
4. | ALA4339117 | ADME | Drug metabolism in human hepatocytes assessed as parent compound remaining by measuring glucuronide formation at 5 uM measured at 120 mins by UPLC-PDA/MS analysis | Homo sapiens | 16 | ALA4334553 | cell-based format | Scientific Literature |