# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4423436 | Functional | Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as reduction in L-AP4-induced calcium flux preincubated for 142 secs followed by agonist addition and measured after 120 secs by Fluo-4-AM-dye based fluorescence assay | Rattus norvegicus | 16 | ALA4422629 | cell-based format | Scientific Literature | |
2. | ALA4423437 | Functional | Negative allosteric modulation of rat mGlu7 receptor expressed in HEK cells harboring Ga15 assessed as calcium flux preincubated for 142 secs followed by agonist addition and measured after 120 secs by Fluo-4-AM-dye based fluorescence assay relative to L-AP4 (minimum) | Rattus norvegicus | 12 | ALA4422629 | cell-based format | Scientific Literature | |
3. | ALA4423439 | ADME | Fraction unbound in Sprague-Dawley rat plasma at 0.2 to 0.25 mg/kg, iv via cassette dosing measured up to 24 hrs post dose by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4422629 | organism-based format | Scientific Literature | |
4. | ALA4423443 | ADME | Unbound fraction in Sprague-Dawley rat brain at 0.2 to 0.25 mg/kg, iv via cassette dosing measured up to 24 hrs post dose by LC/MS/MS analysis | Rattus norvegicus | 5 | ALA4422629 | organism-based format | Scientific Literature |