# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4477768 | Binding | Upregulation of HDAC1 inhibition/ERK signalling activation-mediated extracellular SOD protein expression in human THP1 cells at 100 uM incubated for 24 hrs by ELISA | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
2. | ALA4477769 | Binding | Upregulation of HDAC1 inhibition/ERK signalling activation-mediated extracellular SOD mRNA expression in human THP1 cells at 1 to 10 uM incubated for 24 hrs by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
3. | ALA4477770 | ADME | Cytotoxicity against human THP1 cells assessed as reduction in cell viability at 100 uM after 24 hrs by MTT assay | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
4. | ALA4477771 | Binding | Upregulation of HDAC1 inhibition/ERK signalling activation-mediated extracellular SOD mRNA expression in human THP1 cells at 100 uM by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
5. | ALA4477772 | Binding | Inhibition of HDAC1 in human THP1 cells assessed as increase in histone H4 acetylation level at 50 uM after 12 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
6. | ALA4477773 | Binding | Inhibition of HDAC1 in human THP1 cells assessed as increase in histone H4 acetylation level at 100 uM after 12 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
7. | ALA4477774 | Binding | Inhibition of HDAC1 in human THP1 cells assessed as increase in histone H3 acetylation level at 50 uM after 12 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
8. | ALA4477775 | Binding | Inhibition of HDAC1 in human THP1 cells assessed as increase in histone H3 acetylation level at 100 uM after 12 hrs by Western blot analysis relative to control | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
9. | ALA4477776 | Binding | Upregulation of HDAC1 inhibition-mediated histone H4 acetylation-induced extracellular SOD expression in human THP1 cells at 100 uM after 12 hrs by chromatin immunoprecipitation method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
10. | ALA4477777 | Binding | Upregulation of HDAC1 inhibition-mediated histone H3 acetylation-induced extracellular SOD expression in human THP1 cells at 100 uM after 12 hrs by chromatin immunoprecipitation method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
11. | ALA4477778 | Binding | Induction of ERK phosphorylation in human THP1 cells at 50 to 100 uM incubated for 3 hrs by Western blot analysis | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
12. | ALA4477779 | Binding | Upregulation of HDAC1 inhibition/ERK signalling activation-mediated extracellular SOD mRNA expression in human THP1 cells at 100 uM after 24 hrs in presence of ERK inhibitor U0126 by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
13. | ALA4477780 | Functional | Downregulation of HDAC1 mRNA expression in human THP1 cells at 100 uM after 24 hrs by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
14. | ALA4477781 | Functional | Downregulation of HDAC2 mRNA expression in human THP1 cells at 100 uM after 24 hrs by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
15. | ALA4477783 | Functional | Upregulation of HDAC4 mRNA expression in human THP1 cells at 100 uM after 24 hrs by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
16. | ALA4477784 | Functional | Downregulation of HDAC5 mRNA expression in human THP1 cells at 100 uM after 24 hrs by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
17. | ALA4477785 | Functional | Downregulation of HDAC6 mRNA expression in human THP1 cells at 100 uM after 24 hrs by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
18. | ALA4477786 | Functional | Upregulation of HDAC10 mRNA expression in human THP1 cells at 100 uM after 24 hrs by RT-PCR method | Homo sapiens | 1 | ALA4477194 | cell-based format | Scientific Literature | |
19. | ALA4477787 | Binding | Inhibition of recombinant HDAC1 catalytic domain (unknown origin) using HDAC substrate at 100 uM preincubated for 1 hr followed by substrate addition measured after 30 mins by fluorescence assay relative to control | Homo sapiens | 1 | ALA4477194 | single protein format | Scientific Literature |