# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4359940 | Binding | Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate incubated for 90 mins by fluorescence polarisation assay | Homo sapiens | 36 | ALA4359811 | assay format | Scientific Literature | |
2. | ALA4359941 | ADME | Inhibition of human recombinant full length N-terminal His6-tagged IRAK1 (Argl94 to Ser712 residues) expressed in insect cells using H-KKARFSRFAGSSPSQSSMVAR as substrate incubated for 60 mins by fluorescence polarisation assay | Homo sapiens | 18 | ALA4359811 | cell-based format | Scientific Literature | |
3. | ALA4359943 | Binding | Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase level preincubated for 1 hr followed by LPS stimulation and measured after 20 hrs by quanti-blue reagent based reporter assay | Homo sapiens | 40 | ALA4359811 | assay format | Scientific Literature | |
4. | ALA4359946 | ADME | Apparent permeability from apical to basolateral side in MDCK cells at 10 uM incubated for 180 mins and measured up to 180 min by LC-MS/MS analysis | Canis lupus familiaris | 17 | ALA4359811 | cell-based format | Scientific Literature | |
5. | ALA4359947 | ADME | Protein binding in human plasma at 5 uM incubated for 4 hrs by LC-MS/MS analysis | Homo sapiens | 4 | ALA4359811 | cell-free format | Scientific Literature | |
6. | ALA4359948 | ADME | Protein binding in mouse plasma at 5 uM incubated for 4 hrs by LC-MS/MS analysis | Mus musculus | 4 | ALA4359811 | cell-free format | Scientific Literature | |
7. | ALA4359949 | ADME | Blood clearance in mouse at 1 mg/kg, iv | Mus musculus | 3 | ALA4359811 | organism-based format | Scientific Literature | |
8. | ALA4359950 | ADME | Volume of distribution at steady state in mouse at 1 mg/kg, iv | Mus musculus | 4 | ALA4359811 | organism-based format | Scientific Literature | |
9. | ALA4359951 | ADME | Cmax in mouse at 5 mg/kg, po | Mus musculus | 4 | ALA4359811 | organism-based format | Scientific Literature | |
10. | ALA4359955 | ADME | AUC (infinity) in mouse at 5 mg/kg, po | Mus musculus | 4 | ALA4359811 | organism-based format | Scientific Literature | |
11. | ALA4359959 | ADME | Oral bioavailability in mouse at 5 mg/kg | Mus musculus | 4 | ALA4359811 | organism-based format | Scientific Literature |