# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4359938 | Physicochemical | Kinetic aqueous solubility of the compound in PBS buffer at pH 7.4 incubated for 24 hrs under shaking condition by LC-CLND assay | 25 | ALA4359811 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4359940 | Binding | Inhibition of human recombinant full length His6-tagged IRAK4 expressed in baculovirus expression system using H-KKARFSRFAGSSPSQSSMVAR as substrate incubated for 90 mins by fluorescence polarisation assay | Homo sapiens | 36 | ALA4359811 | assay format | Scientific Literature | |
3. | ALA4359943 | Binding | Inhibition of IRAK4 in human THP1-Xblue-MD2-CD14 cells assessed as reduction in LPS-induced NFkappaB transcription by measuring alkaline phosphatase level preincubated for 1 hr followed by LPS stimulation and measured after 20 hrs by quanti-blue reagent based reporter assay | Homo sapiens | 40 | ALA4359811 | assay format | Scientific Literature | |
4. | ALA4359946 | ADME | Apparent permeability from apical to basolateral side in MDCK cells at 10 uM incubated for 180 mins and measured up to 180 min by LC-MS/MS analysis | Canis lupus familiaris | 17 | ALA4359811 | cell-based format | Scientific Literature |