# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4382057 | Physicochemical | Partition coefficient, logD of the compound at pH 7.4 by HPLC analysis | 24 | ALA4376900 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4382058 | Physicochemical | Kinetic solubility in pH 6.5 phosphate buffer incubated for 30 mins by nephelometry | 24 | ALA4376900 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4382059 | Physicochemical | Kinetic solubility in pH 2.0 0.01M HCl buffer incubated for 30 mins by nephelometry | 24 | ALA4376900 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4382060 | ADME | Intrinsic clearance in human liver microsomes in presence of NADPH-regenerating system incubated over 60 mins | Homo sapiens | 24 | ALA4376900 | microsome format | Scientific Literature | |
5. | ALA4382061 | ADME | Intrinsic clearance in mouse liver microsomes in presence of NADPH-regenerating system incubated over 60 mins | Mus musculus | 24 | ALA4376900 | microsome format | Scientific Literature | |
6. | ALA4382062 | ADME | Protein binding to human albumin by HPLC analysis | Homo sapiens | 24 | ALA4376900 | single protein format | Scientific Literature | |
7. | ALA4382063 | Functional | Antischistosomal activity against Schistosoma mansoni infected in NMRI mouse assessed as reduction in total adult worm burden at 400 mg/kg, po administered as single dose starting on day 49 post-infection and measured at 28 days post treatment relative to control | Schistosoma mansoni | 23 | ALA4376900 | organism-based format | Scientific Literature | |
8. | ALA4382064 | ADME | Cytotoxicity in HFF assessed as reduction in cell viability up to 50 uM incubated for 24 hrs by Alamar blue sye based assay | Homo sapiens | 4 | ALA4376900 | cell-based format | Scientific Literature | |
9. | ALA4382065 | ADME | Cytotoxicity in human U2OS assessed as reduction in cell viability up to 50 uM incubated for 24 hrs by Alamar blue sye based assay | Homo sapiens | 4 | ALA4376900 | cell-based format | Scientific Literature | |
10. | ALA4382066 | ADME | Cytotoxicity in human HEK293T assessed as reduction in cell viability up to 50 uM incubated for 24 hrs by Alamar blue sye based assay | Homo sapiens | 4 | ALA4376900 | cell-based format | Scientific Literature | |
11. | ALA4382067 | ADME | Cytotoxicity in human HC04 assessed as reduction in cell viability up to 50 uM incubated for 24 hrs by Alamar blue sye based assay | Homo sapiens | 4 | ALA4376900 | assay format | Scientific Literature | |
12. | ALA4382068 | Functional | Antischistosomal activity against Schistosoma mansoni infected in NMRI mouse assessed as reduction in total juvenile worm burden at 200 mg/kg, po administered as single dose starting on day 49 post-infection and measured at 28 days post treatment relative to control | Schistosoma mansoni | 4 | ALA4376900 | organism-based format | Scientific Literature |