# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4408390 | Binding | Inhibition of electric eel AChE at 20 uM using acetylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method relative to control | Electrophorus electricus | 77 | ALA4406826 | single protein format | Scientific Literature | |
2. | ALA4408391 | Binding | Inhibition of equine serum BuChE using butyrylthiocholine iodide as substrate preincubated with enzyme for 20 mins followed by substrate addition by Ellman's method | Equus caballus | 31 | ALA4406826 | single protein format | Scientific Literature | |
3. | ALA4408394 | Binding | Mixed inhibition of equine serum BChE assessed as decrease in Vmax at 1 to 5 uM using varying levels of butyrylthiocholine iodide as substrate by Line weaver Burk reciprocal plot analysis | Equus caballus | 1 | ALA4406826 | single protein format | Scientific Literature | |
4. | ALA4408396 | Binding | Mixed inhibition of equine serum BChE assessed as increase in substrate Km at 1 to 5 uM using varying levels of butyrylthiocholine iodide as substrate by Line weaver Burk reciprocal plot analysis | Equus caballus | 1 | ALA4406826 | single protein format | Scientific Literature | |
5. | ALA4408397 | Binding | Non-competitive inhibition of equine serum BChE at 1 to 5 uM using varying levels of butyrylcholine iodide as substrate by Line weaver Burk reciprocal plot analysis | Equus caballus | 1 | ALA4406826 | single protein format | Scientific Literature | |
6. | ALA4408399 | Physicochemical | Octanol-PBS buffer partition coefficient, log P of the compound incubated for 24 hrs measured at pH 7.4 by shake-flask method | 14 | ALA4406826 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4408400 | ADME | Cytotoxicity against human HepG2 cells assessed as cell viability at 5 to 50 uM measured after 24 hrs by MTT assay | Homo sapiens | 2 | ALA4406826 | cell-based format | Scientific Literature | |
8. | ALA4408401 | ADME | Cytotoxicity against rat PC12 cells assessed as cell viability at 5 to 50 uM measured after 24 hrs by MTT assay | Rattus norvegicus | 2 | ALA4406826 | cell-based format | Scientific Literature | |
9. | ALA4408402 | Functional | Neuroprotective activity against H2O2-induced cytotoxicity in rat PC12 cells assessed as increase in cell viability at 10 to 25 uM pretreated for 3 hrs followed by H2O2 stimulation in continuous presence of compound for 24 hrs by MTT assay relative to control | Rattus norvegicus | 2 | ALA4406826 | cell-based format | Scientific Literature | |
10. | ALA4408403 | Binding | Inhibition of equine serum BChE using varying levels of butyrylthiocholine iodide as substrate by Line weaver Burk reciprocal plot analysis | Equus caballus | 2 | ALA4406826 | single protein format | Scientific Literature |