# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4410512 | B | Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis | Homo sapiens | 22 | ALA4406892 | single protein format | Scientific Literature | |
2. | ALA4410522 | A | Cytotoxicity against human MDA-MB-231 cells measured after 48 hrs by MTS assay | Homo sapiens | 3 | ALA4406892 | cell-based format | Scientific Literature | |
3. | ALA4410523 | A | Cytotoxicity against human HepG2 cells measured after 48 hrs by MTS assay | Homo sapiens | 3 | ALA4406892 | cell-based format | Scientific Literature | |
4. | ALA4410524 | A | Cytotoxicity against human HEK293 cells measured after 48 hrs by MTS assay | Homo sapiens | 3 | ALA4406892 | cell-based format | Scientific Literature | |
5. | ALA4410525 | A | Cytotoxicity against human HT1080 cells measured after 48 hrs by MTS assay | Homo sapiens | 3 | ALA4406892 | cell-based format | Scientific Literature | |
6. | ALA4410533 | A | Diuretic activity in Sprague-Dawley rat model of acetazolamide-induced diuresis assessed as increase in sodium excretion at 1.5 mg/kg, ip pretreated with acetazolamide followed by compound treatment measured after 6 hrs | Rattus norvegicus | 2 | ALA4406892 | organism-based format | Scientific Literature | |
7. | ALA4410534 | A | Antikaliuretic activity in Sprague-Dawley rat model of acetazolamide-induced diuresis assessed as decrease in potassium secretion at 1.5 mg/kg, ip pretreated with acetazolamide followed by compound treatment measured after 6 hrs | Rattus norvegicus | 2 | ALA4406892 | organism-based format | Scientific Literature | |
8. | ALA4410535 | B | Inhibition of S3969-stimulated ENaCalpha beta gamma (unknown origin) transfected in HEK293 cells at 10 uM measured after 5 mins by FLIPR assay | Homo sapiens | 2 | ALA4406892 | cell-based format | Scientific Literature | |
9. | ALA4739457 | P | Distribution coefficient, log D of the compound at pH 7.4 by HPLC analysis | 14 | ALA4732263 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4739458 | P | Kinetic solubility of compound in HCL at pH 2 by nephelometric analysis | 14 | ALA4732263 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4739459 | P | Kinetic solubility of compound in PBS at pH 6.5 by nephelometric analysis | 14 | ALA4732263 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4739460 | A | Half life in human liver microsomes at 1 uM up to 60 mins in presence of NADPH | Homo sapiens | 14 | ALA4732263 | microsome format | Scientific Literature | |
13. | ALA4739461 | A | Intrinsic clearance in human liver microsomes at 1 uM up to 60 mins in presence of NADPH | Homo sapiens | 14 | ALA4732263 | microsome format | Scientific Literature | |
14. | ALA4739462 | A | Unbound intrinsic clearance in human liver microsomes at 1 uM up to 60 mins in presence of NADPH | Homo sapiens | 14 | ALA4732263 | microsome format | Scientific Literature | |
15. | ALA4739463 | A | Half life in mouse liver microsomes at 1 uM up to 60 mins in presence of NADPH | Mus musculus | 14 | ALA4732263 | microsome format | Scientific Literature | |
16. | ALA4739464 | A | Intrinsic clearance in mouse liver microsomes at 1 uM up to 60 mins in presence of NADPH | Mus musculus | 14 | ALA4732263 | microsome format | Scientific Literature | |
17. | ALA4739465 | A | Unbound intrinsic clearance in mouse liver microsomes at 1 uM up to 60 mins in presence of NADPH | Mus musculus | 14 | ALA4732263 | microsome format | Scientific Literature | |
18. | ALA4739466 | A | Plasma protein binding in Balb/C mouse at 1 ug/ml after 4.2 hrs by LC-MS analysis | Mus musculus | 6 | ALA4732263 | cell-free format | Scientific Literature | |
19. | ALA4739467 | A | Drug degradation in Balb/C mouse plasma at 1 ug/ml after 4 hrs by LC-MS analysis | Mus musculus | 6 | ALA4732263 | cell-free format | Scientific Literature | |
20. | ALA4739468 | A | Stability in Balb/C mouse whole blood assessed as drug degradation at 1 ug/ml after 2 hrs by LC-MS analysis | Mus musculus | 6 | ALA4732263 | tissue-based format | Scientific Literature |