| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4370145 | Binding | Inhibition of full length recombinant PIM1 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins followed by biotinylated BAD addition and measured after 1 hr by HTRF assay | Homo sapiens | 27 | ALA4368910 | single protein format | Scientific Literature | |
| 2. | ALA4370146 | Binding | Inhibition of full length recombinant PIM2 (unknown origin) assessed as reduction in BAD phosphorylation at Ser112 residues preincubated for 30 mins followed by biotinylated BAD addition and measured after 1 hr by HTRF assay | Homo sapiens | 27 | ALA4368910 | single protein format | Scientific Literature | |
| 3. | ALA4370147 | Binding | Inhibition of PIM1/PIM2/PIM3 in human KMS-12-BM cells assessed as reduction in BAD phosphorylation after 110 mins by flow cytometric analysis | Homo sapiens | 27 | ALA4368910 | cell-based format | Scientific Literature | |
| 4. | ALA4370148 | ADME | Intrinsic clearance in human liver microsomes at 1 uM after 30 mins in presence of NADPH | Homo sapiens | 27 | ALA4368910 | microsome format | Scientific Literature | |
| 5. | ALA4370149 | ADME | Intrinsic clearance in rat liver microsomes at 1 uM after 30 mins in presence of NADPH | Rattus norvegicus | 27 | ALA4368910 | microsome format | Scientific Literature | |
| 6. | ALA4370150 | Physicochemical | Solubility of the compound in phosphate buffer solution at pH 7.4 incubated for 1 hr in shaker and subsequently equilibrated for 72 hrs by LC/MS analysis | 27 | ALA4368910 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4370151 | Physicochemical | Solubility of the compound in in fasted state simulated intestinal fluid at pH 6.8 incubated for 1 hr in shaker and subsequently equilibrated for 72 hrs by LC/MS analysis | 27 | ALA4368910 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4370152 | Physicochemical | Solubility of the compound in in 0.01N HCl at pH 2 incubated for 1 hr in shaker and subsequently equilibrated for 72 hrs by LC/MS analysis | 27 | ALA4368910 | small-molecule physicochemical format | Scientific Literature |
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