| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4327371 | Binding | Inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in HEK293F cells pretreated for 15 mins followed by substrate and [3H]-SAM addition measured after 60 mins by scintillation proximity assay | Homo sapiens | 25 | ALA4325864 | cell-based format | Scientific Literature | |
| 2. | ALA4327372 | Binding | Inhibition of PRMT1 (unknown origin) pretreated for 15 mins followed by substrate and [3H]-SAM addition measured after 60 mins by scintillation proximity assay | Homo sapiens | 1 | ALA4325864 | single protein format | Scientific Literature | |
| 3. | ALA4327373 | Binding | Inhibition of PRMT4 (unknown origin) pretreated for 15 mins followed by substrate and [3H]-SAM addition measured after 60 mins by scintillation proximity assay | Homo sapiens | 1 | ALA4325864 | single protein format | Scientific Literature | |
| 4. | ALA4327374 | Binding | Competitive inhibition of recombinant human N-terminal FLAG-tagged PRMT5 (2 to end residues) /human N-terminal His-tagged MEP50 (2 to end residues) expressed in HEK293F cells pretreated for 15 mins followed by varying peptide substrate and and fixed [3H]-SAM addition measured after 60 mins by scintillation proximity assay | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 5. | ALA4327375 | Functional | Antiproliferative activity against human MV4-11 cells after 4 days by cell titer-glo luminescent cell viability assay | Homo sapiens | 2 | ALA4325864 | cell-based format | Scientific Literature | |
| 6. | ALA4327376 | Functional | Antiproliferative activity against human Pfeiffer cells after 4 days by cell titer-glo luminescent cell viability assay | Homo sapiens | 2 | ALA4325864 | cell-based format | Scientific Literature | |
| 7. | ALA4327377 | Functional | Antiproliferative activity against human SU-DHL4 cells after 4 days by cell titer-glo luminescent cell viability assay | Homo sapiens | 2 | ALA4325864 | cell-based format | Scientific Literature | |
| 8. | ALA4327378 | Functional | Antiproliferative activity against human KARPAS422 cells after 4 days by cell titer-glo luminescent cell viability assay | Homo sapiens | 2 | ALA4325864 | cell-based format | Scientific Literature | |
| 9. | ALA4327379 | Binding | Inhibition of PRMT5 in human KARPAS422 cells assessed as decrease in symmetric arginine dimethylation of SmD3 after 4 days by Western blot analysis | Homo sapiens | 2 | ALA4325864 | cell-based format | Scientific Literature | |
| 10. | ALA4327380 | Binding | Inhibition of PRMT5 in human SU-DHL4 cells assessed as decrease in symmetric arginine dimethylation of SmD3 after 4 days by Western blot analysis | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 11. | ALA4327381 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as viable cells at 4 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 91.3%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 12. | ALA4327382 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as apoptotic cells at 4 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 4.08%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 13. | ALA4327383 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as necrotic cells at 4 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 3.20%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 14. | ALA4327384 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as viable cells at 8 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 91.3%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 15. | ALA4327385 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as apoptotic cells at 8 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 4.08%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 16. | ALA4327386 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as necrotic cells at 8 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 3.20%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 17. | ALA4327387 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as viable cells at 16 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 91.3%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 18. | ALA4327388 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as apoptotic cells at 16 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 4.08%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 19. | ALA4327389 | Functional | Induction of apoptosis in human KARPAS422 cells assessed as necrotic cells at 16 uM after 48 hrs by AnnexinV-FITC staining-based flow cytometric analysis (Rvb = 3.20%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature | |
| 20. | ALA4327390 | Functional | Cell cycle arrest in human KARPAS422 cells assessed as accumulation of cells at G1 phase at 4 uM after 48 hrs by propidium iodide staining-based flow cytometric analysis (Rvb = 39.56%) | Homo sapiens | 1 | ALA4325864 | cell-based format | Scientific Literature |
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