| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4379571 | B | Inhibition of recombinant N-terminal 6x-His-tagged c-KIT (547 to 935 residues)/(694 to 753 residues deletion) (unknown origin) expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr) 4:1 as substrate measured after 150 mins in presence of ATP by ADP-glo reagent based luminescence assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 2. | ALA4379572 | B | Inhibition of wild type recombinant GST-tagged FLT3 (Y567 to S993 residues) (unknown origin) expressed in baculovirus infected Sf9 insect cells using Her2 peptide as substrate measured after 4 hrs in presence of ATP by Kinase-Glo Plus reagent-based luminescence assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 3. | ALA4379573 | F | Antiproliferative activity against human GISTT1 cells harboring heterozygous deletion mutation at C-kit exon 11 assessed as cell growth inhibition after 72 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 4. | ALA4379574 | F | Antiproliferative activity against human MOLM13 harboring FLT3-ITD mutant assessed as cell growth inhibition after 72 hrs by CellTiter 96 AQueous One Solution Cell Proliferation assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 5. | ALA4379575 | B | Inhibition of human c-KIT JM domain exon 11 V560G single mutant at 100 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 6. | ALA4379576 | B | Inhibition of human c-KIT JM domain exon 11 V560G single mutant at 10 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 7. | ALA4379577 | B | Inhibition of human c-KIT ATP binding domain exon 13 V654A single mutant at 100 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 8. | ALA4379578 | B | Inhibition of human c-KIT ATP binding domain exon 13 V654A single mutant at 10 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 9. | ALA4379579 | B | Inhibition of human c-KIT ATP binding domain exon 13 K642E single mutant at 100 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 10. | ALA4379580 | B | Inhibition of human c-KIT ATP binding domain exon 13 K642E single mutant at 10 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 11. | ALA4379581 | B | Inhibition of human c-KIT ATP binding domain exon 14 T670I single mutant at 100 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 12. | ALA4379582 | B | Inhibition of human c-KIT ATP binding domain exon 14 T670I single mutant at 10 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 13. | ALA4379583 | B | Inhibition of human c-KIT A loop exon 17 D816H single mutant at 100 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 14. | ALA4379584 | B | Inhibition of human c-KIT A loop exon 17 D816H single mutant at 10 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 15. | ALA4379585 | B | Inhibition of human c-KIT A loop exon 17 D816V single mutant at 100 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 16. | ALA4379586 | B | Inhibition of human c-KIT A loop exon 17 D816V single mutant at 10 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 17. | ALA4379587 | B | Inhibition of human c-KIT A loop exon 17 D820E single mutant at 100 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 18. | ALA4379588 | B | Inhibition of human c-KIT A loop exon 17 D820E single mutant at 10 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 19. | ALA4379589 | B | Inhibition of human c-KIT A loop exon 17 D820Y single mutant at 100 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature | ||
| 20. | ALA4379590 | B | Inhibition of human c-KIT A loop exon 17 D820Y single mutant at 10 nM using poly (Glu,Tyr) 4:1 as substrate in presence of 33P-gamma-ATP by hotspot kinase assay relative to control | Homo sapiens | 3 | single protein format | Scientific Literature |
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